The body weight and serum lipid levels in ApoE-/- mice treated with or without NAC or LST.

<p>Neither NAC nor LST changes the body weight and serum lipid levels of high-fat-fed ApoE^-/-mice. ApoE^-/- mice were fed with a chow diet or high fat diet and were oral administered with NAC (1mg/mL) or LST (10 mg/kg/day) for 16 weeks. <strong>A</strong> growth curves of body weight; <strong>B</strong> serum TG; <strong>C</strong> TC and <strong>D </strong>LDL-C levels in ApoE^-/- mice. Plots are means &plusmn; SD.* <em>p</em>&lt;0.05 and **<em>P </em>&lt;0.01. Experiments were performed on male mice, n=8 per group. AS, atherosclerosis; Con, control; LDL-C, low density lipoprotein&nbsp;cholesterol; LST, losartan; NAC, N-Acetyl-L-cysteine; n.s. not significant; TC, total cholesterol; TG, triglyceride.</p>