Processed MERFISH datasets for brain aging (coronal, sagittal) and rejuvenation (exercise, partial reprogramming)

<p>This repository contains several AnnData ".h5ad" objects containing the processed MERFISH data and metadata for the datasets generated in our study:</p> <blockquote> <p>"aging_coronal.h5ad" - the aging coronal section dataset</p> <p>"aging_sagittal.h5ad" - the aging sagittal section dataset</p> <p>"exercise.h5ad" - exercise dataset</p> <p>"reprogramming.h5ad" - partial reprogramming dataset</p> </blockquote> <p>&nbsp;</p> <p>Key metadata are saved as observation annotations in each object, and include:</p> <blockquote> <p>"mouse_id" - identifier for mouse from which the cell was derived</p> <p>"slide_id" - identifier for MERSCOPE slide</p> <p>"batch" - A and B denote different experimental batches for MERFISH</p> <p>"age" - mouse age in months</p> <p>"cohort" - experimental condition / group</p> <p>"celltype" - cell type annotation</p> <p>"region" - brain region annotation</p> <p>"subregion" - brain subregion annotation (will be more variabile/noisy than region)</p> </blockquote>