Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment - Validation mIF

<p>mIF object from&nbsp;<em>spatialTIME</em> R package, calculating univariate Ripley's K on multiplex immunofluorescence images stained with FOXP3, CD8, CD68, ITGAV, COL4, VIM, SMA, and PCK. Data was processed with InForm and HALO.&nbsp;</p> <p>Clear cell renal cell carcinoma and papillary renal cell carcinoma were profiled before and after exposure to immunotherapy, with and without sarcomatoid features in clear cell tumors. Each tumor had a field of view in the stromal compartment and field of view in the tumor compartment.</p> <p>For appropriate clinical information associated with this study, please contact Dr. Brandon Manley.</p>