APARENT2 Genome-wide In-silico Saturation Mutagenesis

<p>In-silico saturation mutagenesis predictions for all polyadenylation signals found in PolyADB V3 using the APARENT2 model (transcript-wide). The file &#39;aparent2_ism_scores_polyadb_v3.csv.gz&#39; contains all data. The file &#39;aparent2_ism_scores_polyadb_v3_cutoff.csv.gz&#39; contains only variants with more than 1.25-fold increase or decrease in isoform odds. The data columns &#39;delta_logodds&#39; and &#39;delta_usage&#39; contain variant isoform log odds ratios and isoform proportion differences (wrt. PolyADB measurements) for polyadenylation occurring anywhere +/- 100bp of the canonical cleavage site. The columns &#39;delta_logodds_narrow&#39; and &#39;delta_usage_narrow&#39; contains log odds ratios and proportion differences for cleaveage that occurs +0bp to +50bp immediately downstream of the canonical core hexamer motif. The data columns &#39;pas_position_hg19&#39; and &#39;pas_position_hg38&#39; indicate the start coordinate of the core hexamer.</p>