Simultaneous profiling of histone modifications and DNA methylation via nanopore sequencing

<p>Datasets that contain a minimum of nanopore&nbsp;reads sufficient for&nbsp;hidden Markov model&nbsp;training&nbsp;and for evaluating the performance of our computational tool - nanoHiMe at simultaneously&nbsp;calling&nbsp;CpG and/or adenine methylation on individual nanopore reads.<em> Ecoli</em>_PCR_amplicons_100k.tgz, <em>Ecoli</em>_PCR_MSssI_100k.tar.gz and <em>Ecoli</em>_PCR_pA-Hia5_100k.tar.gz are&nbsp;used for&nbsp;training new parameters of the emission distributions of individual <em>k</em>-mers from DNA template without modification, with fully methylated CpGs, and with partially methylated adenines, respectively. nanoHiMe_H3K27me3.fast5.tgz are the nanopore sequencing reads from H3K27me3 nanoHiMe-seq experiments in GM12878 cells&nbsp;and used for evaluating&nbsp;the performance of&nbsp;nanoHiMe&nbsp;at jointly calling CpG and adenine methylation.</p>