Effects of medication intake on the risk of haemorrhage in patients with sporadic cerebral cavernous malformations

<p>Objective:</p> <p>Recurrent intracerebral hemorrhage (ICH) poses a high risk for patients with cerebral cavernous malformations (CCMs). This study aimed to assess the influence of medication intake on hemorrhage risk in sporadic CCMs.</p> <p>Results:</p> <p>A total of 1116 patients with CCM were included. Logistic regression analysis showed a significant correlation (OR: 0.520, 95% CI: 0.284–0.951, p = 0.034) between antithrombotic therapy and ICH as a mode of presentation. Cox regression analysis revealed no significant correlation between medication intake and occurrence of (re-)hemorrhage (hazard ratios: betablockers 1.270 [95% CI: 0.703–2.293], statins 0.543 [95% CI: 0.194–1.526], antithrombotic therapy 0.507 [95% CI: 0.182–1.410], and thyroid hormones 0.834 [95% CI: 0.378–1.839]).</p> <p>Conclusion:</p> <p>In this observational study, antithrombotic treatment was associated with the tendency to a lower rate of ICH as a mode of presentation n a large cohort of patients with sporadic CCM. Intake of beta blockers, statins, and thyroid hormones had no eect on hemorrhage as a mode of presentation. During the 5-year follow-up period, none of the drugs aected the further risk Q7 of (re-)hemorrhage.</p>