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Data for: Predicting m7G sites used by autoBioSeqpy

<p>As a vital post-transcriptional RNA modification, N<sup>7</sup>-methylguanosine plays a key role in the regulation of gene expression. Precise identification of the m<sup>7</sup>G sites is a crucial first step toward understanding its biological function and regulatory mechanisms. Although whole-genome sequencing is the gold standard for RNA modification site detection, it is time-consuming, expensive, and relatively complex. In recent years, computational approaches have become increasingly popular in achieving this goal, especially with the rise of deep learning techniques. Some deep learning algorithms, such as convolutional neural networks (CNNs) and recurrent neural networks (RNNs), have emerged as versatile approaches for modeling biological sequence data. However, designing a successful network architecture with excellent performance remains a challenge because it requires substantial professional knowledge and commitment of time and effort. We previously developed a tool called autoBioSeqpy to efficiently design and apply deep learning networks for the classification of biological sequences. autoBioSeqpy has many unique features that make it a practical tool for a broad range of biological questions. In this work, we used autoBioSeqpy to develop, train, evaluate and analyze sequence-level deep learning models for predicting the m<sup>7</sup>G sites. We here provided a detailed description of the various models it implements, as well as a step-by-step guide on how to execute them. The same strategy can also be applied in other systems to address similar biological questions.  </p>

ShareScore

40/100

Overall dataset sharing score

Score breakdown

These five areas show where the dataset supports — or may limit — practical reuse.

Stewardship
4
Harmonization
12
Access
12
Reuse readiness
0
Engagement
12

Topics

Dataset details

Repository
dryad
Published
December 25, 2022
License
cc-zero
DOI
10.5061/dryad.ht76hdrks

Scored with release 0.9.0

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