Modulating Synchrotron Microbeam Radiation Therapy Doses for Preclinical Brain Cancer Supplementary

<p>Figure S1 shows the valley depth dose curves compared to the average 9LGS tumor volume variation with depth of each treatment group in Table 1 (except group 5 at 13.8 Gy).<strong> </strong>When including the 5 mm bolus, the valley dose plateau is shifted to cover the entire tumor volume of the group 3 and 6 animals which improves the valley dose consistency (shown in Figures S1A and S1B, respectively). Without the bolus, the superior portion of these tumors (&lt;5.5 mm depth) would receive less dose than the desired target doses of 8 and 15 Gy. Note that for programs 3 and 6, the bolus was in place for treatment. Tumors that were treated with programs 2 and 5 (with no bolus) were subject to the limited valley dose coverage (in Figures S1C and S1D, respectively), and expected to have reduce survival for some individuals.</p>