Dataset related to the article "Effects of RAGE Deletion on the Cardiac Transcriptome during Aging"

<p>This record contains raw data related to the article&ldquo;Effects of RAGE Deletion on the Cardiac Transcriptome during Aging&rdquo;</p> <p><strong>Abstract</strong></p> <p>Cardiac aging is characterized by increased cardiomyocyte hypertrophy, myocardial stiffness, and fibrosis, which enhance cardiovascular risk. The receptor for advanced glycation end-products (RAGE) is involved in several age-related diseases. RAGE knockout (Rage&minus;/&minus;) mice show an acceleration of cardiac dimension changes and interstitial fibrosis with aging. This study identifies the age-associated cardiac gene expression signature induced by RAGE deletion. We analyzed the left ventricle transcriptome of 2.5-(Young), 12-(Middle age, MA), and 21-(Old) months-old female&nbsp;Rage&minus;/&minus;&nbsp;and C57BL/6N (WT) mice. By comparing Young, MA, and Old&nbsp;Rage&minus;/&minus;&nbsp;versus age-matched WT mice, we identified 122, 192, and 12 differently expressed genes, respectively. Functional inference analysis showed that RAGE deletion is associated with: (i) down-regulation of genes involved in antigen processing and presentation of exogenous antigen, adaptive immune response, and cellular responses to interferon beta and gamma in Young animals; (ii) up-regulation of genes related to fatty acid oxidation, cardiac structure remodeling and cellular response to hypoxia in MA mice; (iii) up-regulation of few genes belonging to complement activation and triglyceride biosynthetic process in Old animals. Our findings show that the age-dependent cardiac phenotype of&nbsp;Rage&minus;/&minus;&nbsp;mice is associated with alterations of genes related to adaptive immunity and cardiac stress pathways.</p>