Partial dataset related to the article "Prognostic Impact of Extra–Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation"

<p>This record contains partial&nbsp;raw data related to the article &quot;Prognostic Impact of Extra&ndash;Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation&quot;</p> <p>OBJECTIVES The aim of this study was to evaluate the prognostic impact of the presence of extra&ndash;mitral valve cardiac</p> <p>involvement (including known risk factors but also severe left atrial [LA] dilatation and right ventricular [RV] dysfunction)</p> <p>in a large multicenter study of patients with primary mitral regurgitation (MR).</p> <p>BACKGROUND In patients with severe primary MR, the indication for surgery is currently based on the presence of</p> <p>symptoms, left ventricular dilatation and dysfunction, atrial fibrillation, and pulmonary hypertension.</p> <p>METHODS Patients with severe primary MR undergoing surgery were included and categorized according to the extent</p> <p>(highest) of cardiac involvement: group 0, no cardiac involvement; group 1, left ventricular involvement; group 2, LA</p> <p>involvement; group 3, pulmonary vasculature or tricuspid valve involvement; or group 4, RV involvement. The outcome</p> <p>was all-cause mortality.</p> <p>RESULTS A total of 1,106 patients were included (mean age 63 12 years, 68% male). In total, 377 patients (34%)</p> <p>were classified in group 0, 239 (22%) in group 1, 213 (19%) in group 2, 180 (16%) in group 3, and 97 (9%) in group 4.</p> <p>Kaplan-Meier curve analysis revealed significantly worse survival (log-rank chi-square &frac14; 43.4; P &lt; 0.001) with higher</p> <p>group. On multivariable analysis, age, male sex, chronic obstructive pulmonary disease, kidney function, and group of</p> <p>cardiac involvement were independently associated with all-cause mortality. For each increase in group, a 17% higher risk</p> <p>for all-cause mortality was observed (95% CI: 1.051-1.313; P &frac14; 0.005) during a median follow-up time of 88 months.</p> <p>CONCLUSIONS In patients with severe primary MR, a novel classification system based on extra&ndash;mitral valve cardiac</p> <p>involvement may help refine risk stratification and timing of surgery, particularly including severe LA dilatation and RV</p> <p>dysfunction in the assessment.</p>