Atopic dermatitis and DNA methylation at birth: findings from epigenome-wide meta-analyses

<p>Meta-analyses results from &quot;Atopic dermatitis and DNA methylation at birth: findings from epigenome-wide meta-analyses&quot;. This data contains summary statistics from 12 meta-analyses of EWAS of atopic dermatitis (AD) using DNA methylation measured using the Illumina Infinium HumanMethylation450 BeadChip. Details on the analyses can be found in the paper.&nbsp;</p> <p>Each of the files are tab-separated with the following column names (description in brackets):</p> <ul> <li>CpG</li> <li>Beta (the effect estimate)</li> <li>SE (standard error)</li> <li>P (P value)</li> <li>Direction (Direction of effect within each cohort)</li> <li>Het_ISq (I2 value of heterogeneity)</li> <li>Het_P (P value from Cochran&rsquo;s Q-test for heterogeneity)</li> </ul> <p>The files are named in the following way: `AD-PHENOTYPE_MODEL_COHORT-STRAT.tsv`</p> <p>AD-PHENOTYPE: childhood, early-onset, or persistent.<br> MODEL: Model A, B, or C (see paper for details)<br> COHORT-STRAT: If the cohorts were stratified in anyway here is where it will be indicated. DD = AD was defined by doctor diagnosis only, DD-R = AD was defined by doctor diagnosis and/or rash symptoms, HR = AD was defined using the Hanifin-Rajka criteria.&nbsp;</p> <p>For example, the file `childhood_model-C_DD.tsv` contains the summary statistics from the meta-analysis of EWAS of AD within cohorts that defined AD using doctor diagnosis only.&nbsp;</p>