Simulated eukaryotic genomic sequencing, long and short reads

<p><span>As accuracy and throughput of nanopore sequencing improves, it is increasingly common to perform long-read-first </span><em>de novo</em> genome assemblies followed by polishing with accurate short reads (Kim et al. 2021). We briefly introduce FMLRC2, the successor to the original FM-index Long Read Corrector (FMLRC), and illustrate its performance as a fast and accurate <em>de novo</em> assembly polisher for both bacterial and eukaryotic genomes.</p>