Memory or naive T cell origin of VZV gE-specific T cell clonotypes boosted by zoster vaccination.

<p>Subjects were vaccinated with either the live attenuated zoster vaccine (n=5) or recombinant zoster vaccine (n=10). Peripheral blood mononuclear cells were obtained before vaccination (baseline), at peak response&nbsp;approximately one month after vaccination, and after 5 years. The TRB sequences for VZV gE-specific T cell clonotypes were identified from CD4 T cells that proliferated in response to overlapping peptides spanning the&nbsp;VZV gE protein. To assess if the vaccines recruited responses from existing memory or from naive T cells, VZV gE-specific clonotypes were cross-matched to naive and memory CD4 T cell subsets isolated from baseline PBMC.</p> <p>This dataset contains the raw TRB sequences obtained using the Adaptive Biotechnologies Immunoseq platform for:</p> <p>1) peak gE clonotypes</p> <p>2) year 5 gE clonotypes</p> <p>3) baseline memory CD4 T cell subsets</p> <p>4) baseline naive CD4 T cell subsets.</p>