Cobalt(III)-Catalyzed Enantioselective Intermolecular Carboamination by C−H Functionalization

<p>High-valent cyclopentadienyl cobalt catalysis is a versatile tool for sustainable C&minus;H bond functionalizations. To harness the full potential of this strategy, control of the stereoselectivity of these processes is necessary. Herein, we report highly enantioselective intermolecular carboaminations of alkenes through C&minus;H activation of&nbsp;<em>N</em>-phenoxyamides catalyzed by Co^III-complexes equipped with chiral cyclopentadienyl (Cp^x) ligands. The method converts widely available acrylates as well as bicyclic olefins into attractive enantioenriched isotyrosine derivatives as well as elaborated amino-substituted bicyclic scaffolds under very mild conditions. The outlined reactivity is unique to the Cp^xCo^III&nbsp;complexes and is complementary to the reactivity of 4d- and 5d- precious-metal catalysts.</p>