Temporal changes of gene expression in health and mental disorders. Supporting Data

<p>This dataset provides data necessary to replicate the results of the time-perturbation analysis of gene expression in health and mental disorders. The corresponding code is available in the GitHub repository <a href="https://github.com/susieavagyan/BrainExp-TemporalDynamics">https://github.com/susieavagyan/BrainExp-TemporalDynamics</a>․</p> <p>The content of the data archive is following:</p> <ul> <li><strong>"GTEX_unzipped"</strong> folder contains &nbsp;GTEx single-tissue cis-eQTL dataset (v8)</li> <li><strong>"pheno"</strong> folder &nbsp;contains sample phenotype data for datasets used in the analysis&nbsp;</li> <li><strong>"scRNA-Ruzicka_data"</strong> folder &nbsp;contains gene signatures for neuronally associated processes and brian cell populations from Ruzicka, W. Brad, Shahin Mohammadi, Jose Davila-Velderrain, Sivan Subburaju, Daniel Reed Tso, Makayla Hourihan, and Manolis Kellis. 2020. &ldquo;Single-Cell Dissection of Schizophrenia Reveals Neurodevelopmental-Synaptic Axis and Transcriptional Resilience.&rdquo; MedRxiv, January, 2020.11.06.20225342. https://doi.org/10.1101/2020.11.06.20225342 paper.</li> <li><strong>"v5_results.SOM - Results"</strong> folder &nbsp;contains the transcriptome analysis results generated with oposSOM pipeline &nbsp;</li> <li><strong>"BM.table.Rdata"</strong> file contains gene symbol ENSEMBL ID conversion table required for eQTL analysis&nbsp;</li> <li><strong>"Brain_development_v3.Rdata"</strong> file contains combined raw gene expression data of datasets used in this analysis</li> <li><strong>"som_input_v5.Rdata"</strong> file contains batch adjusted and normalized gene expression matrix that was used as an input for oposSOM pipeline.</li> </ul>