Fig. 10 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 10. Synthesis of isolaxifolin (369). Reagents and conditions: (a) 3-methyl-2-butenal, Ca(OH), MeOH, 18 ◦ C, 72 h; (b) Ac O, CH Cl, 18 ◦ C, 6 h; (c) 3-methyl-2- 2 2 2 2 buten-1-ol, DEAD, PPh, THF, 0–18 ◦ C, 6 h; (d) Eu(fod), CHCl, 60 ◦ C, 6 h; (e) K CO, MeOH, 0 ◦ C, 1 h.