Fig. 5. G in The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review

Fig. 5. G. lutea extract and its constituents could inhibit vascular smooth muscle cells proliferation acting downstream of PDGF-receptor but upstream ERK1/2 leading to the slackening of the atherosclerotic process. At the same time, amarogentin could inhibit MAPKs and PLCγ activation avoiding platelet activation.