Fig. 5 in Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors

Fig. 5. Anti-ferroptosis activity of 1–7. (A) The neuroprotective effect of 1–7 in PC12 cells. (B) EC50 values of 2, 3 and 7. (C) C3 inhibited erastin-induced PC12 cells damage. Scale bar, 50 μm. (D) C3 suppressed erastin-induced ROS accumulation in PC12 cells. (E) C3 suppressed MDA accumulation in PC12 cells. Data were expressed as the mean ± SEM. ###P <0.001, ##P <0.01 vs control group. ***P <0.001, **P <0.01, *P <0.05 vs erastin group.