Fig. 5 in Isoindolines and phthalides from the rhizomes of Ligusticum chuanxiong and their relaxant effects on the uterine smooth muscle

Fig. 5. The effects of compounds 4–10 and 12 on oxytocin-induced contractions of isolated rat uteruses. OT (0.008 U/mL) is the abbreviation for oxytocin. VER (0.5 μM) is the abbreviation for verapamil hydrochloride, a positive control. A: Inhibitory effects of compounds 4–10 and 12 on oxytocin-induced contractions of isolated rat uterus. B: Effects of compounds 4–10 and 12 on the contractile activity of the isolated rat uterus. C: Effects of compounds 4–10 and 12 on the contractile tension of the isolated rat uterus. D: Effects of compounds 4–10 and 12 on the contractile frequency of the isolated rat uterus. The data are expressed as the mean ± SEM (n = 6). * indicates p <0.05 and ** indicates p <0.01 compared to the solvent control.