Fig. 1 in Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease

Fig. 1. Functions of SARS-CoV-2 PLpro and benefits by targeting PLpro. (A) PLpro proteolyzes viral polyprotein at the LXGG site to generate mature nsp1, nsp2 and nsp3. (B) PLpro removes ISG15 and ubiquitin modifiers from host proteins to evade innate antiviral immunity.