Fig. 3. The C21 in Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities

Fig. 3. The C21 steroid compounds (1–28) exhibited DOX resistance reversing activity (A) Cell viability following treatment with compounds 1–28. (B) CI value for DOX and the isolated compounds in HepG2/ ADM and MCF7/ADR cells. (C) Intersection diagram for DOX and 50% of the steroid compounds with the highest IC50 values at the same concentration. (D) Molecular docking model findings for the computer simulation of the multidrug resistance-associated protein (P-gp) and the steroid compounds.