Fig. 5 in Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

Fig. 5. The top-scored docking poses of 19 in hBuChE (A, B; PDB ID: 4BDS) and the crystal structure of tacrine bound to hBuChE (C, D). The ligands are displayed in blue (A) and green (C) for 19 and tacrine, respectively; important amino acid residues responsible for ligand anchoring are shown in grey for hBuChE (A, C). Catalytic triad residues are displayed in yellow (A, C). Important interactions are rendered by black dashed lines; distances are measured in angstroms (Å). The rest of the receptor is displayed in light-grey cartoon conformation (A, C). Figures A and C were created with The PyMOL Molecular Graphics System, Version 2.4.1, Schr¨odinger, LLC. 2D figures (B, D) were generated with Maestro 12.3 (Schr¨odinger Release, Schr¨odinger, LLC, New York, NY, 2020). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)