Fig. 17 in The scope of flavin-dependent reactions and processes in the model plant Arabidopsis thaliana

Fig. 17. Reduction of 5,10-methylene tetrahydrofolate to 5-methyl-tetrahydrofolate by methylenetetrahydrofolate reductase. In the plant enzyme, NADH is used to reduce the FAD cofactor. The reaction proceeds via hydride transfer, probably to the carbon (highlighted in red) and subsequent protonation of the nitrogen (reductive cleavage). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)