Fig. 8 in Genomic insights into the biosynthesis and physiology of the cyanobacterial neurotoxin 2,4-diaminobutanoic acid (2,4-DAB)

Fig. 8. The localisation of the enzymes diaminobutanoate-2-oxo-glutarate transaminase, the downstream decarboxylase, and ectoine synthase within siderophore clusters and incomplete ectoine clusters. The top three clusters correspond to NIS clusters and the bottom cluster corresponds to an incomplete ectoine cluster. The organisation of NIS clusters follows the same pattern: diaminobutanoate-2-oxo-glutarate transaminase (EC 2.6.1.76), followed by diaminobutanoate decarboxylase (EC 4.1.1.86) and IucA/IucC (EC 6.3.2.38, EC 6.3.2.39) family siderophore biosynthesis protein. Arrows point to the orientation of transcription. AntiSMASH was used to identify and annotate specialised metabolite clusters containing both 2,4-DAB transaminase and decarboxylase or 2,4-DAB transaminase and ectoine synthase (EC 4.2.1.108).