Fig. 5. Compounds 2 and 17 in Isolation, identification, and activity evaluation of diterpenoid alkaloids from Aconitum sinomontanum

Fig. 5. Compounds 2 and 17 exhibited potent inhibitory effects on the capsaicin mediated activation of TRPV1 channels expressed in HEK-293 cells. (A) Inhibition rate by compounds on the capsaicin mediated activation of TRPV1 channels expressed in HEK-293 cells. Compounds 1, 2, and 17 were evaluated at the concentration of 10 μM, the other compounds were evaluated at the concentration of 100 μM. (B) Activation of TRPV1 by capsaicin (0.5 μM), and inhibition of TRPV1 current by compound 2. Data are presented as the means ± SEM from three independent tests.