Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548)

<p>Dataset for the project &quot;LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases&quot; (GR-2016-02362548).</p> <p><strong>Aim 1:</strong></p> <p>Understanding whether LRRK2 mediates neuroinflammation triggered by PD and AD misfolded proteins using in vitro and in vivo models.</p> <p><strong>Aim 2:</strong></p> <p>Exploring whether and how LRRK2-related neuroinflammation affects hiPSC-derived neuronal function.</p> <p><strong>Aim 3:</strong></p> <p>Exploring whether hiPSC-derived neurons carrying LRRK2 mutation/variant are more vulnerable to neuroinflammation.</p> <p>&nbsp;</p> <p>The present dataset contains the following folders:</p> <p><strong>1- Aim 1</strong></p> <p>- In vitro</p> <p>&nbsp; &nbsp;- Attivazione infiammazione</p> <p>&nbsp; &nbsp;- Generazione proteina amiloide</p> <p>&nbsp; &nbsp;- LRRK2 infiammazione</p> <p>- In vivo</p> <p>&nbsp; &nbsp;-&nbsp;Generazione proteina amiloidi</p> <p>&nbsp; &nbsp;- Infiammazione abeta</p> <p>&nbsp; &nbsp;- Infiammazione asyn</p> <p>&nbsp; &nbsp;- Microglia-Astrociti abeta</p> <p>&nbsp; &nbsp;- Microglia-Astrociti asyn&nbsp;&nbsp;</p> <p>&nbsp;</p> <p><strong>2- Aim 2</strong></p> <p>- hiPSC Col RNASeq</p> <p>- hiPSC DA RNASEq</p> <p>- Neuroni colinergici</p> <p>- Neuroni dopaminergici</p> <p>&nbsp;</p> <p><strong>3- Aim 3</strong></p> <p>- Gentotyping human cells</p>