Fig. 10 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 10. Binding pose of 15 with human Pgp. The P-gp model was generated based on the PDB structure of human P-gp (Code: 6QEX) and was portrayed as a cartoon (light green). Residues involved in the interaction were colored yellow, while the surfaces of the hydrophobic pocket packing with 15 were colored light brown red. The hydrogen bonds and hydrophobic forces were shown as red dashed lines and yellow dashed lines, respectively. The structural figures were drawn in Accelrys Discovery Studio 2016. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)