Fig. 3 in Triterpene glycosides from Blighia welwitschii and evaluation of their antibody recognition capacity in multiple sclerosis

Fig. 3. Data distribution of IgM antibody responses to saponins 2, 6, 7, hederagenin monodesmoside and giganteaside J from B. welwitschii as well as Glc oleanolate from O. obtusifolia, in the sera of multiple sclerosis (MS) and ctrl patients, determined by ELISA. CSF114(Glc) and the unglucosylated peptide CSF114 were tested as controls. Data are reported as absorbance at 405 nm of sera diluted 1:100. Horizontal lines represent mean values with their SD. MannWitney U test showed that MS and ctrl distributions significantly differ for CSF114(Glc), CSF114 (p value <0.0001, two-tailed) and for Glc oleanolate (p value <0.05, two-tailed). In contrast, saponins 2, 6, 7, hederagenin monodesmoside and giganteaside J did not show any statistical differences between the two sera distributions (p value> 0.05, two-tailed).