Fig. 10 in Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds for treatment of secretory diarrhea

Fig. 10. Anti-diarrheal application of compound 10 (A) Effect of compound 10 on CT-induced chloride secretion in T84 cells. (B) Effect of compound 10 on CT-induced intestinal fluid secretion in mouse close-loop. Ileal loops were instilled with phosphate-buffered saline (PBS) or PBS containing cholera toxin (1 μg/loop) with or without intraluminal (i.l.) administration of compound 10 (16.9 μg/loop). Loop weight/length ratios were evaluated 6 h after CT challenges. ***, P <0.001 when compared with control ###, P <0.001 when compared with the CT-treated group (one-way ANOVA) (n = 5).