Fig. 9 in Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds for treatment of secretory diarrhea

Fig. 9. Effect of compound 10 on intestinal CaCC activity. (A) Representative trace of apical IClˉ. T84 cell monolayers were permeabilized with amphotericin B at basolateral membrane, and 5 μM of CFTRinh-172 was applied to apical solution 15 min prior to addition of ATP (100 μM). Compound 10 was then added to both apical and basolateral solution at indicated concentration. (B) Data were fitted to the Hill equation and expressed as means of ATP-induced IClˉ ± S.E.M. (n = 3).