Tissue-specific Regulatory Network from Badr's work

<p>Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type- and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoters and genes. Integration with 37 genome-wide association studies (GWASs) showed that disease-associated genetic variants--including variants that do not reach genome-wide significance--often perturb regulatory modules that are highly specific to disease-relevant cell types or tissues. Our resource opens the door to systematic analysis of regulatory programs across hundreds of human cell types and tissues (http://regulatorycircuits.org).</p> <p>hs_blood_network.rds : human blood related&nbsp; gene regulatory networks (R program data file)</p> <p>hs_pantissue_network.rds :&nbsp;human pan-tissue related&nbsp; gene regulatory networks&nbsp;(R program data file)</p> <p>mm_blood_network.rds : mouse&nbsp;blood related&nbsp; gene regulatory networks&nbsp;&nbsp;(R program data file)</p> <p>mm_pantissue_network.rds :&nbsp;mouse pan-tissue related&nbsp; gene regulatory networks&nbsp;(R program data file)</p> <ul> <li>PMID:&nbsp;<strong>26950747</strong></li> <li>PMCID:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4967716/">PMC4967716</a></li> <li>DOI:&nbsp;<a href="https://doi.org/10.1038/nmeth.3799">10.1038/nmeth.3799</a></li> </ul>