Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning: Summary statistics

<p>Summary statistics for a genome-wide association study (GWAS) of Alzheimer&#39;s disease CSF biomarkers principal components (PCs). This dataset accompanies the publication &quot;Multivariate GWAS of Alzheimer&rsquo;s disease CSF biomarker profiles implies GRIN2D in synaptic functioning&quot;. The article is currently in press at Genome Medicine. A link will be provided upon publication, but see the medRxiv preprint in the meantime:</p> <p>Neumann, A., Ohlei, O., K&uuml;&ccedil;&uuml;kali, F., Bos, I. J., Vos, S., Prokopenko, D., ... &amp; Kristel Sleegers &amp; Lars Bertram. (2022). Multivariate GWAS of Alzheimer&rsquo;s disease CSF biomarker profiles implies GRIN2D in synaptic functioning. <em>medRxiv</em>, 2022-08. https://doi.org/10.1101/2022.08.02.22278185</p> <p>A GWAS was performed for five different PC biomarkers.</p> <p>PC1: Tau pathology/degeneration</p> <p>PC2: A&beta; Pathology</p> <p>PC3: Injury/inflammation</p> <p>PC4: Non-AD inflammation</p> <p>PC5: Non-AD synaptic functioning</p> <p>Each GWAS was performed in either males and females (&quot;all&quot;), in females only (&quot;female&quot;), or in males only (&quot;male&quot;). In addition, we also ran an interaction model with sex as moderator (&quot;interaction&quot;). Each file includes output of the meta-analysis between the EMIF-AD study and ADNI.</p> <p>The files contain following columns:</p> <p>CHROM: Chromosome</p> <p>POS: Position according to Build 37</p> <p>ID: Chromosome:Position</p> <p>A1: Effect allele</p> <p>A2: Other allele</p> <p>BETA: Effect of one copy of the effect allele on biomarker PCs in SD. In case of sex interaction, the effect specific to females.</p> <p>SE: Standard Error</p> <p>P: p-value</p> <p>D: Direction in ADNI and EMIF-AD respectively</p> <p>Het: Heterogeneity statistics (I², and corresponding &chi;², degrees of freedom and p-value)</p>