Exploring the anti-glioma mechanism of the active components of Cortex Periplocae based on network pharmacology and iTRAQ proteomics in vitro

<p>Hierarchical clustering analysis of candidate proteins was illustrated in heat map, which showed obvious differences between CP-induced cells and controls (Fig. 6). Each column is a sample and each rowindicates a differentially expressed protein. Log values (log₂expression) of significantly differentially expressed proteins in different samples are displayed in heat maps in different colors. GreenandRedrepresent&nbsp;up-regulation&nbsp;and down-regulation, respectively. The gray part represents no quantitative information of the proteins. T1, T2 and T3 means the CP-treated U251 cells group and C2, C2 and C3 means control group (n=3).</p>