Beta-lactam polyspecificity in E. coli

<p>This image dataset supports the findings in our manuscript entitled&nbsp;<a href="https://doi.org/10.1021/acschembio.9b00141">Morphological deconvolution of beta-lactam polyspecificity in&nbsp;<em>E. coli.&nbsp;</em></a></p> <p>The images display fluorescently-labeled&nbsp;<em>E. coli</em> strains subjected to compound treatment at multiple concentrations. Cells were imaged in 96-well plates at 100X magnification.&nbsp;Our novel method for preparing&nbsp;<em>E. coli&nbsp;</em>cells for imaging enabled us to use commercially-available plate-based, automated HCI microscopes.&nbsp;&nbsp;We used the images to build our <a href="https://doi.org/10.1093/bioinformatics/btx069">deep neural network classifier </a>to identify bacterial morphologies as well as our Hidden Markov models for target deconvolution.</p> <p>&nbsp;</p>