Male mouse 60d water uranium exposure

Male mice were exposed to uranium in the drinking water for 60 days. Doses of uranium (in the form of uranyl acetate) were 0, 5, and 50 ppb. We examined 1) immune function of splenocytes (mitogenesis) 2) lymphocyte population subsets in the bone marrow, spleen and thymus (flow cytometry) 3) erythroid cell differentiation in the bone marrow (flow cytometry) 4) uranium concentrations in kidney, femur bone, liver, blood spleen thymus and bone marrow (ICP-MS).