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2,774
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2,774 results for “Agent”
A Study of MBG453 in Combination With Hypomethylating Agents in Subjects With IPSS-R Intermediate, High or Very High Risk Myelodysplastic Syndrome (MDS).
ClinicalTrials.gov study NCT03946670. IPD Sharing: YES. Countries: 17. Publications: 1.
Phase Ib/II Study of INC280 + PDR001 or PDR001 Single Agent in Advanced HCC
ClinicalTrials.gov study NCT02795429. IPD Sharing: YES. Countries: 8. Publications: 1.
A Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of TAK-079 Administered Subcutaneously as a Single Agent in Participants With Relapsed/Refractory (r/r)
ClinicalTrials.gov study NCT03439280. IPD Sharing: YES. Countries: 1. Publications: 1.
Phase 1/2 Study of Amcenestrant (SAR439859) Single Agent and in Combination With Other Anti-cancer Therapies in Postmenopausal Women With Estrogen Receptor Positive Advanced Breast Cancer
ClinicalTrials.gov study NCT03284957. IPD Sharing: YES. Countries: 10. Publications: 1.
Data from: Do biological control agents adapt to local pest genotypes? A multi-year test across geographic scales
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Identification of infectious agents in early marine Chinook and Coho salmon associated with cohort survival
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Data from: Differing agents of physical damage to artificial seedlings in remnant and restored forests
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Supplementary data for: Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Ppara-null mouse livers
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Supplementary data for: Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARa, PPARg, and cytotoxic agents in wild-type and PPARa knockout mouse hepatocytes
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Alternative Covid-19 mitigation measures in school classrooms: Analysis using an agent-based model of SARS-CoV-2 transmission
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Supplementary data for: Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARa, PPARg, and cytotoxic agents in mouse, rat, and pooled human hepatocytes
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Climate matching models for Ceratapion basicorne (Coleoptera: Apionidae), a biocontrol agent of yellow starthistle
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Pre - application of dentin bonding agent prevents discoloration caused by mineral trioxide aggregate
<p>we provide the data regarding the effect of dentin bonding agent which could help prevent discoloration caused by mineral trioxide aggregate.</p>
Data from: Genome assembly of the ragweed leaf beetle, a step forward to better predict rapid evolution of a weed biocontrol agent to environmental novelties
<p><span>Rapid evolution of weed biological control agents (BCAs) to new biotic and abiotic conditions is poorly understood and so far, only little considered both in pre-release and post-release studies, despite potential major negative or positive implications for risks of non-targeted attacks or for colonizing yet unsuitable habitats, respectively. Provision of genetic resources, such as assembled and annotated genomes, is essential to assess potential adaptive processes by identifying underlying genetic mechanisms. Here, we provide the first sequenced genome of a phytophagous insect used as a BCA, <i>i.e.</i> the leaf beetle <i>Ophraella communa</i>, a promising BCA of common ragweed, recently and accidentally introduced into Europe. A total 33.98 Gb of raw DNA sequences, representing c. 43-fold coverage, were obtained using the PacBio SMRT-Cell sequencing approach. Among the five different assemblers tested, the SMARTdenovo assembly displaying the best scores was then corrected with Illumina short reads. A final genome of 774 Mb containing 7,003 scaffolds was obtained. The reliability of the final assembly was then assessed by benchmarking universal single-copy orthologous genes (> 96.0% of the 1,658 expected insect genes) and by remapping tests of Illumina short reads (average of 98.6% ± 0.7% without filtering). The number of protein-coding genes of 75,642, representing 82% of the published antennal transcriptome, and the phylogenetic analyses based on 825 orthologous genes placing <i>O. communa </i>in the monophyletic group of Chrysomelidae, confirm the relevance of our genome assembly. Overall, the genome provides a valuable resource for studying potential risks and benefits of this BCA facing environmental novelties.</span></p>
An experimental application of Hypena opulenta as a biocontrol agent for the invasive vine Vincetoxicum rossicum
<p>1. Pre-release testing for biological control agents is focused primarily on assessment of host-range specificity and safety of potential agents. Agent impact is considered pre-release, however the ultimate assessment of an agent must occur following release in the field under the target population levels and conditions of the invaded ecosystems. The invasive Eurasian vine, Vincetoxicum rossicum, has spread aggressively through its invaded range of eastern North America since its initial introduction in the late 1800's. In laboratory tests, the Eurasian moth Hypena opulenta has shown great promise as a potential control agent for V. rossicum.</p> <p>2. We were interested in the defoliating ability of H. opulenta and its subsequent effect on the seed production of V. rossicum under field conditions. To examine this, we established a field site near Kirkfield, Ontario that consisted of meadow and forest understory plots, both of which were highly invaded by V. rossicum.</p> <p>3. We report highly significant feeding by H. opulenta in both light conditions. Unexpectedly, we observed a significant increase in seed production following folivory in shade conditions. We observed no significant effect of larval folivory on seed production under sun conditions, where V. rossicum seed production is greater by a factor of ten as compared to shade conditions.</p> <p>4. Synthesis and application: It is unclear how continuous exposure to folivory by H. opulenta will affect mature V. rossicum stands, although it might be expected that such populations would invest in defenses to herbivory, possibly at the expense of reproductive output. In order to better understand if V. rossicum populations in either light condition could exhibit longer-term compensatory growth in response to folivory, further experimental work is needed that examines inter-annual variability in V. rossicum reproduction at variable H. opulenta densities.</p>
Nano MOFs as targeted drug delivery agents to combat antibiotic resistant bacterial infections
<p>The drug resistance of bacteria is a significant threat to human civilization while the action of antibiotics against drug-resistant bacteria is severely limited due to the hydrophobic nature of drug molecules, which unquestionably inhibit its permanency for clinical applications. The antibacterial action of nanomaterials offers major modalities to combat drug resistance of bacteria. The current work reports, the use of nano MOFs encapsulating drug molecules to enhance its antibacterial activity against model drug-resistant free living bacteria and biofilm of the bacteria. We have attached rifampicin (RF), a well-documented antituberculosis drug with tremendous pharmacological significance, into the pore surface of zeolitic imidazolate framework 8 (ZIF8) by a <span><span>simple synthetic procedure</span></span><span>.</span> The synthesized ZIF8 has been characterized using X-ray diffraction (XRD) method before and after drug encapsulation. The electron microscopic strategies such as scanning electron microscope (SEM) and transmission electron microscope (TEM) methods was performed to characterize the binding between ZIF8 and RF. We have also performed picosecond resolved fluorescence spectroscopy to validate the formation of the ZIF8-RF nanohybrids (NHs). The drug release profile experiment demonstrates that ZIF8-RF depicts pH-responsive drug delivery and ideal for targeting bacterial disease corresponding to its inherent acidic nature. Most remarkably, ZIF8-RF gives enhanced antibacterial activity against methicillin-resistant <i>S. aureus</i> (MRSA) bacteria and also prompts entire damage of structurally robust bacterial biofilms. Overall, the present study depicts a detailed physical insight for manufactured antibiotic-encapsulated NHs presenting tremendous antimicrobial activity that can be beneficial for manifold practical applications.</p>
Agent-based Testing of Extended Reality Systems
<p>Testing for quality assurance (QA) is a crucial step in the development of Extended Reality (XR) systems that typically follow iterative design and development cycles. Bringing automation to these testing procedures will increase the productivity of XR developers. However, given the complexity of the XR environments and the User Experience (UX) demands, achieving this is highly challenging. We propose to address this issue through the creation of autonomous cognitive test agents that will have the ability to cope with the complexity of the interaction space by intelligently explore the most prominent interactions given a test goal and support the assessment of affective properties of the UX by playing the role of users.</p>
Data from: Disturbance detection in Landsat time series is influenced by tree mortality agent and severity, not by prior disturbance
<p><span>Landsat time series (LTS) and associated change detection algorithms are useful for monitoring the effects of global change on Earth's ecosystems. Because LTS algorithms can be easily applied across broad areas, they are commonly used to map changes in forest structure due to wildfire, insect attack, and other important drivers of tree mortality. But factors such as initial forest density, tree mortality agent, and disturbance severity (i.e., percent tree mortality) influence patterns of surface reflectance and may influence the accuracy of LTS algorithms. And while LTS algorithms are widely used in areas with a history of multiple disturbance events during the Landsat record, the effectiveness of LTS algorithms in these conditions is not well understood. We compared products from the LTS algorithm LandTrendr (<span>Landsat-based Detection of Trends in Disturbance and Recovery) with</span> a unique field dataset from a landscape heavily influenced by both wildfire and spruce beetles (<i>Dendroctonus rufipennis</i>) since c. 2000. We also compared LandTrendr to other common methods of mapping fire- and spruce beetle-affected areas. We found that LandTrendr more accurately detected wildfire than spruce beetle-induced tree mortality, and both mortality agents were more easily detected when they occurred at high severity. Surprisingly, prior spruce beetle outbreaks did not influence the detectability of subsequent wildfire. Compared to alternative disturbance mapping approaches, LandTrendr predicted a c. 40% lower area affected by wildfire or spruce beetle outbreaks. <span>Our findings indicate that disturbance type- and severity-specific differences in omission error may have broad implications for disturbance mapping efforts that utilize Landsat data. Gradual, low-severity disturbances (e.g., background tree mortality and non-stand replacing disturbance) are pervasive in forest ecosystems, yet they can be difficult to detect using automated LTS algorithms. Whenever possible, methods to account for these biases should be incorporated in LTS-based mapping efforts, including the use of multispectral ensembles and ancillary spatial data to refine predictions. However, our findings also indicate that LTS algorithms appear to be robust in areas with multiple disturbance events, which is important because these areas will increase as new acquisitions extend the length of the Landsat record. </span></span></p>
Data from: A novel, porcinated human Butyrylcholinesterase catalytically degrades the chemical warfare nerve agent, sarin
<p>Chemical warfare nerve agents (CWNAs) present a global threat to both military and civilian populations. The acute toxicity of CWNAs stems from their ability to effectively inhibit acetylcholinesterase (AChE). This inhibition can lead to uncontrolled cholinergic cellular signaling, resulting in cholinergic crisis and, ultimately, death. While the current FDA-approved standard of care is moderately effective when administered early, development of novel treatment strategies is necessary. Butyrylcholinesterase (BChE) is an enzyme which displays a high degree of structural homology to AChE. Unlike AChE, the roles of BChE are uncertain and possibilities are still being explored. However, BChE appears to primarily serve as a bioscavenger of toxic esters due to its ability to accommodate a wide variety of substrates within its active site. Like AChE, BChE is also readily inhibited by CWNAs. Due to its high affinity for binding CWNAs, and that null-BChE yields no apparent health effects, exogenous BChE has been explored as a candidate therapeutic for CWNA intoxication. Despite years of research, minimal strides have been made to develop a catalytic bioscavenger. Further, BChE is only in early clinical trials as a stoichiometric bioscavenger of CWNAs, and large quantities must be administered to treat CWNA toxicity. Here we describe previously unidentified mutations to residues within and adjacent to the acyl binding pocket (positions 282-285 were mutagenized from YGTP to NHML) of BChE that confer catalytic degradation of the CWNA, sarin. These mutations, along with corresponding future efforts, may finally lead to a novel therapeutic to combat CWNA intoxication.</p>
Ensemble Metatone Agent and App Study Data (2014-07-19)
<p>This repository contains recordings of performances made by Ensemble Metatone (Christina Hopgood, Yvonne Lam, and Jonathan Griffiths) as part of a formal study of touch-screen apps and ensemble director agents. Video recordings as well as touch-data logs are included for each of the 18 performances.</p> <p>Three apps were used in the sessions: Snow Music (SM), Bird’s Nest (BN), and Singing Bowls (SB). Two agents were used: a gesture classifying agent (CLA), and an agent that generated similar signals from a statistical model (GEN) that was not connected to the performers’ actions.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.