Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
451
datasets available to search
ShareScore release 0.9.0
Dataset results
451 results for “Angiogenesis”
Effect of CAR-M2 hydrogel treatment on the expression of related genes such as fibrosis and endothelial angiogenesis in mice with renal fibrosis (bulk RNA-seq)
GEO Series GSE282078. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Cdh5]
GEO Series GSE233357. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
A Regulatory microRNA Network Controls Endothelial Cell Phenotypic Switch During Sprouting Angiogenesis [RNA-Seq]
GEO Series GSE115817. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells (miRNA-seq)
GEO Series GSE138114. Homo sapiens. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Effect of neurotrophin p75 receptor (p75NTR) on angiogenesis
GEO Series GSE9910. Mus musculus. 8 samples. Type: Expression profiling by array.
Angiogenin Released from ABCB5+ Stromal Precursors Improves Healing of Diabetic Wounds by Promoting Angiogenesis
GEO Series GSE181881. Homo sapiens; Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Data from: VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-β play important roles in promoting immature and inflammatory intraplaque angiogenesis
Various angiogenic factors have been shown to play important roles in intraplaque angiogenesis, while little is known about the dynamic expression change and interplay between various angiogenic factors and intraplaque angiogenesis under high cholesterol conditions. New Zealand rabbits underwent balloon injury of the abdominal artery and then were assigned to a control group (n=15, normal chow) or high cholesterol group (n=25, 1% high cholesterol diet). At weeks 4, 6, 8, 10, and 12 after acclimation, rabbits (high cholesterol group, n=5; control group, n=3) were euthanized. No lesions were observed in the control group. From week 4 to week 12, the expression of vascular endothelial growth factor A (VEGF-A), VEGF receptor 2 (VEGFR-2), fibroblast growth factor 2 (FGF-2), FGF receptor 1 (FGFR-1), platelet-derived growth factor-BB (PDGF-BB), and tumor necrosis factor alpha (TNF-α), the vulnerabilty index (VI) and the microvessel density (MVD) were significantly elevated in the high cholesterol group; however, PDGF receptor β (PDGFR-β) expression showed little change. Analysis by double-label immunofluorescence (CD31 and Ng2) and FITC-dextran indicated that the neovessels within the plaque were leaky due to a lack of pericytes. As indicated by Pearson's correlation analysis, there was a highly positive correlation between the VI, MVD, macrophage content, and TNF-α level, and the levels of VEGF-A/VEGFR-2 and FGF-2/FGFR-1. However, no correlations were observed between PDGFR-β levels and the VI or MVD. High expression of VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not of PDGF-BB/PDGFR-β may contribute to immature and inflammatory intraplaque angiogenesis and plaque instability in a rabbit model of atherosclerosis
miR-126-3p contributes to parathyroid tumor angiogenesis
<p>Tumors of the parathyroid glands are highly vascularized and display a microRNA (miRNA) profile divergent from normal parathyroid glands (PaNs). Angiogenic miRNAs, namely miR-126-3p, miR-126-5p, and miR-296-5p, have been found downregulated in parathyroid tumors. Here, we show that miR-126-3p expression levels are reduced in parathyroid adenomas (PAds; n = 12) compared with PaNs (n = 4). In situ hybridization (ISH) of miR-126-3p and miR-296-5p in 10 PAds show that miR-126-3p is expressed by endothelial cells lining the walls of great vessels and by cells within the thin stroma surrounding acinar structures. At variance, miR-296-5p was detectable in most PAd epithelial cells. Combining ISH for miR-126-3p with immunohistochemistry for the endothelial and mesenchymal markers CD34, CD31 and α-smooth muscle actin (αSMA), we could identify that miR-126-3p is localized in the αSMA-positive thin stroma. Further, miR-126-3p-expressing cells are enriched in the CD34-positive stromal cells surrounding epithelial cell acinar structures, a cellular pattern consistent with tumor-associated myofibroblasts (TAMs). In line with this, CD34-positive cells, sorted by FACS from PAds tissues, express miR-126-3p at higher levels than CD34-negative cells, suggesting that miR-126-3p downregulation promotes the endothelial-to-αSMA+ mesenchymal transition. In human mesenchymal stem cells derived from bone marrow (hBM-MSCs), a model of TAMs, the co-culture with PAds-derived cells for 5 days decreases miR-126-3p, while it increases VEGFA expression. At variance, adrenomedullin (ADM) expression is unaffected. Finally, overexpression of the miR-126-3p mimic in both hBM-MSCs and PAds-derived explants downregulates VEGFA expression levels. In conclusion, miR-126-3p is expressed by both endothelial cells and TAMs in PAds, and its downregulation promotes neoangiogenesis, possibly through VEGFA overexpression.</p>
NOGA Angiogenesis Revascularization Therapy: Evaluation by RadioNuclide Imaging - The Northern Trial
ClinicalTrials.gov study NCT00143585. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Sofosbuvir-daclatasuvir on Angiogenesis
ClinicalTrials.gov study NCT03646396. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Study of the Angiogenesis by PET/CT in Patients With Lymphoma
ClinicalTrials.gov study NCT02490891. IPD Sharing: Not stated. Countries: 1. Publications: 0.
68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Angiogenesis in Ischemic Heart Disease
ClinicalTrials.gov study NCT03505346. IPD Sharing: NO. Countries: 1. Publications: 0.
Gefitinib With Chemotherapy or Anti-angiogenesis in NSCLC Patients With Bim Deletion or Low EGFR Mutation Abundance
ClinicalTrials.gov study NCT03267654. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Anti-Angiogenesis Therapy Using Thalidomide in Multiple Myeloma
ClinicalTrials.gov study NCT00083577. IPD Sharing: Not stated. Countries: 1. Publications: 0.
RGD-PET-CT in Cancer Angiogenesis
ClinicalTrials.gov study NCT01492192. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma
ClinicalTrials.gov study NCT04069273. IPD Sharing: NO. Countries: 1. Publications: 0.
PET/CT Imaging of Angiogenesis in Lung or Head and Neck Cancers Prior or During Chemotherapy With Antiangiogenic Agents
ClinicalTrials.gov study NCT02325349. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Von Willebrand Factor and Its Multimers on Angiogenesis
ClinicalTrials.gov study NCT04810702. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Myocardial Angiogenesis
ClinicalTrials.gov study NCT03445884. IPD Sharing: NO. Countries: 1. Publications: 0.
Hyperbaric Oxygen Therapy in Patients With Chronic Stable Ischemic Heart Disease: An Option for Therapeutic Angiogenesis?
ClinicalTrials.gov study NCT02760394. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.