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2,408
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Dataset results
2,408 results for “Atrial fibrillation”
Atrial Fibrillation Recurrence in Sleep Apnea
ClinicalTrials.gov study NCT00263757. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures
ClinicalTrials.gov study NCT01107730. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Study for Safety and Acute Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System Used With Fast Ablation Mode in Treatment of Patients With Paroxysmal Atrial Fibrillation.
ClinicalTrials.gov study NCT03459196. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Atrovastatin for Preventing Atrial Fibrillation Following Open Cardiac Valve Repair
ClinicalTrials.gov study NCT02084069. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter
ClinicalTrials.gov study NCT01914926. IPD Sharing: Not stated. Countries: 1. Publications: 13.
The FARAPULSE ADVENT PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation
ClinicalTrials.gov study NCT04612244. IPD Sharing: NO. Countries: 1. Publications: 2.
The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation
ClinicalTrials.gov study NCT00579098. IPD Sharing: Not stated. Countries: 1. Publications: 5.
AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment
ClinicalTrials.gov study NCT03732794. IPD Sharing: YES. Countries: 1. Publications: 0.
Explore the Efficacy and Safety of Once-daily Oral Rivaroxaban for the Prevention of Cardiovascular Events in Subjects With Nonvalvular Atrial Fibrillation Scheduled for Cardioversion
ClinicalTrials.gov study NCT01674647. IPD Sharing: Not stated. Countries: 17. Publications: 2.
Ablation Verses Anti-arrhythmic Therapy for Reducing All Hospital Episodes From Recurrent Atrial Fibrillation
ClinicalTrials.gov study NCT02459574. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery
ClinicalTrials.gov study NCT00903370. IPD Sharing: Not stated. Countries: 2. Publications: 2.
A Safety and Feasibility Study of the FARAPULSE Endocardial Ablation System to Treat Paroxysmal Atrial Fibrillation
ClinicalTrials.gov study NCT03714178. IPD Sharing: UNDECIDED. Countries: 2. Publications: 1.
Intravenous Cardioversion of Atrial Fibrillation (AF) With AZD1305
ClinicalTrials.gov study NCT00915356. IPD Sharing: Not stated. Countries: 8. Publications: 1.
DiamondTemp™ Ablation System for the Treatment of Paroxysmal Atrial Fibrillation
ClinicalTrials.gov study NCT03334630. IPD Sharing: NO. Countries: 5. Publications: 2.
Quality of life among patients with atrial fibrillation
Open the record for dataset details and reuse information.
Direct oral anticoagulants in atrial fibrillation patients with concomitant hyperthyroidism
Objective <p>Patients with hyperthyroidism were excluded from randomized clinical trials of direct oral anticoagulants(DOACs) for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).</p> Methods <p>We performed a nationwide retrospective cohort study using data from the Taiwan National Health Insurance Research Database. We enrolled 3,213 and 1,181 NVAF patients with hyperthyroidism taking DOACs and warfarin, respectively, from June 1, 2012 to December 31, 2017. We also enrolled 53,591 and 16,564 NVAF patients without hyperthyroidism taking DOACs and warfarin, respectively. We used propensity score-based stabilized weights (PSSWs) to balance covariates across the study groups. We also used 1:4 matching on both taking DOACs, with (n=3,213) and without hyperthyroidism (n=12,852); and both taking warfarin, with (n=1,181) and without hyperthyroidism (n=4,724).</p> Results <p>After PSSW, DOAC had a comparable risk of ischemic stroke/systemic embolism (IS/SE) and a lower risk of major bleeding (hazard ratio (HR):0.65; [95% confidential interval (CI):0.44-0.96]; <i>P</i>=0.0295) than warfarin among patients with hyperthyroidism. There were comparable risks of IS/SE and major bleeding between those patients with and without hyperthyroidism. However, patients taking warfarin with hyperthyroidism had a lower risk of IS/SE than those without hyperthyroidism (HR:0.61; [95%CI:0.43-0.86]; <i>P</i>=0.0050).</p> Conclusion <p>Among NVAF Asian patients with concomitant hyperthyroidism, DOACs may be an effective and safer alternative to warfarin. Thromboprophylaxis with DOACs may be considered for such patients, and it is important to validate this finding in further prospective study.</p>
Data from: Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery
Background: Although microRNA (miRNA) regulates initiation and/or progression of atrial fibrillation (AF) in canine AF models, the underlying mechanism in humans remains unclear. We speculated that certain miRNAs in atrial tissue are related to AF, and evaluated the relationship of miRNA expression in human atrial tissue in cardiac surgery patients. Methods: Right atrial tissues from 29 patients undergoing cardiovascular surgery were divided into 3 groups [A: chronic AF or unsuccessful maze, n=6; B: successful maze, n=10; C: sinus rhythm (SR) n=13]. miRNA expression was determined using high density microarrays and with Reverse transcriptase-polymerase chain reaction (RT-PCR). Fibrosis was examined using Masson trichrome staining. Results: miRNA microarray analysis showed elevated miRNA-21, miRNA-23b, miRNA-199b, and miRNA-208b in AF as compared to SR groups. RT-PCR showed elevated miRNA-21 (1.9-fold) and miRNA-208b (4.2-fold) in AF as compared to the SR groups. miRNA-21 expression increased from Group C to A (A: 2.1-fold, B: 1.8-fold, C: 1.0-fold). Fibrosis increased from C to A (A: 43.0±12.9%, B: 21.3±6.1%, C: 11.9±3.1%). Percent fibrosis and miRNA-21 expression were correlated (r=0.508, p<0.05). The plasma levels of miRNA-21 in AF patients was significantly decreased as compared to the healthy volunteers (p<0.05). Conclusion: The expression of miRNA-21 in human atrial tissue was found to be related to atrial fibrosis and might affect AF occurrence, indicating its usefulness as a biomarker for cardiac surgery management.
Long-term electrocardiogram and wrist-based photoplethysmogram recordings with annotated atrial fibrillation episodes
<p><strong>Rationale</strong></p> <p>Atrial fibrillation (AF) has emerged as a worldwide cardiovascular epidemic affecting more than 33 million individuals worldwide and carrying a 5-fold increased risk of brain stroke and a 3-fold increased risk of heart failure (Hindricks et al. 2021). AF is a progressive disease, with primary paroxysmal episodes being self-terminating; therefore, the success of complication management highly depends on early arrhythmia detection, which often requires long-term AF monitoring (Keach et al. 2015). Unfortunately, existing devices for long-term AF monitoring are either expensive (implantable cardiac monitors) or inconvenient due to skin irritation (Holter monitors, electrocardiogram (ECG) patches). Thus, it is desirable to develop inexpensive technologies ensuring wearing comfort. Recently, biooptical photoplethysmography (PPG) signal has emerged as such technology with immense potential for convenient long-term AF monitoring (Pereira et al. 2020). However, due to the lack of guidelines for arrhythmia interpretation in PPG, simultaneous ECG recording is needed for verification of the episodes detected in PPG. The present dataset contains simultaneously acquired wrist-based PPG and reference ECG signals with annotated AF episodes, and thus, is particularly suitable for use in the development and testing of automatic PPG-based AF detectors.</p> <p><strong>Subjects and data acquisition protocol</strong></p> <p>The dataset contains long-term ECG and PPG signals from 45 patients with suspected AF monitored for 5 to 8 days (306 days in total). Detailed demographic (sex, age, height, weight) and clinical (diagnosed comorbidities, medications) characteristics of the patients are provided in the supplementary file <strong><em>subject_info.xlsx</em></strong>.</p> <p>The acquisition of the PPG and ECG signals was started at Vilnius University Hospital Santaros Klinikos (Vilnius, Lithuania) and continued for a week at the patient’s home. The PPG signal was acquired at a sampling frequency of 100 Hz using a green LED embedded in a wrist-worn device developed at the Biomedical Engineering Institute (Kaunas, Lithuania). The reference ECG signal was acquired at a sampling frequency of 500 Hz using the Bittium Faros™ 180 ECG device together with the Bittium OmegaSnap™ patch electrode (Oulu, Finland). Additionally, triaxial acceleration signals were acquired with both devices at sampling frequencies of 50 and 25 Hz using wrist-worn and reference ECG devices, respectively. The occurrence times of QRS-complexes in ECG signals were obtained using an open-source QRS detector (Moeyersons et al. 2020), and initial AF episodes were automatically detected using a low-complexity AF detector relying on rhythm irregularity information (Petrėnas et al. 2015). Then, the AF detector output was visually inspected and manually corrected by medical specialists experienced in arrhythmia diagnosis with the aim to find undetected and discard falsely detected episodes.</p> <p>The data acquisition protocol was in accordance with the ethical principles of the Declaration of Helsinki and was approved by Vilnius Region Biomedical Research Ethics Committee (No. 158200-18/7-1052-557). All patients gave written informed consent to participate.</p> <p><strong>Technical details</strong></p> <p>The acquired signals are provided in MAT-files named as follows:</p> <p><strong>XX_YYY</strong>,</p> <p>where <strong>XX</strong> is the patient ID, <strong>YYY</strong> is ECG for the signals from the Bittium Faros™ 180 ECG device and PPG for the signals from the wrist-worn device. For each patient, there are a single continuous ECG recording and multiple PPG recordings because the acquisition of the PPG could be interrupted for a short time due to technical reasons or for a longer time to allow battery charging of the wrist-worn device.</p> <p>In addition to PPG, ECG, and acceleration signals, each file contains a signal header, the day when the recording started with respect to the first monitoring day of the patient, and the time of day when the recording started. The ECG files also contain QRS time indices and calculated RR intervals together with AF annotations on a beat-to-beat basis. PPG and acceleration signals from a wrist-worn device were synchronized to correspond time of ECG acquisition device. </p> <p>In the <strong><em>subject_info.xlsx</em></strong> file, physical inactivity is defined as < 5000 steps/day or < 150 min/week of moderate-intensity exercise or < 75 min/week of high-intensity exercise, excessive physical activity is defined as > 750 min/week of moderate-intensity exercise, and hypertension is classified into stages based on systolic/diastolic blood pressure: stage I corresponding to 140/90–159/99 mmHg, stage II to 160/100–179/109 mmHg, and stage III to ≥ 180/100 mmHg.</p> <p><strong>Limitations</strong></p> <p>When using the resource, researchers should be aware that the PPG and ECG acquisition devices have been synchronized, however, the exact alignment of the signals cannot be reached due to physiological features, e.g., the heart rate obtained from the PPG and ECG signals. Users should also be aware that the sampling frequencies of the devices can vary slightly.</p>
Prospective in-silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion - Supplement
<p>The dataset contains a Supplemental Material for the paper "<strong>Prospective in-silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion</strong>", <em>DOI:</em> <span>10.1113/JP287124</span></p> <p>Moreover, it includes 10 simulations conducted in a representative cohort of 10 non-cardioverted virtual patients that originally presented sustained AF for 5 seconds after drug simulation. The new simulations were run for 5 additional seconds, for a total duration of 10 seconds of simulated pharmacological action. The two drug treatments resulting in lower cardioversion efficacy (i.e., single SK and K2P channel block) were considered. </p>
The differential inflammatory infiltration and gene expression in left and right atrium in patients with atrial fibrillation
<p><strong>Background: </strong>The difference between left and right atrium in Atrial fibrillation (AF) is still lacking. In the present study, we aimed to identify differences in immune infiltration and differentially expressed genes (DEGs) between atrial tissue in patients with AF and sinus rhythm (SR), and to compare the differences between left and right atrial tissues in AF.</p> <p><strong>Methods:</strong> The gene data of GSE79768, GSE115574, and GSE128188 from the Gene Expression Omnibus (GEO) database were retrieved. After merging all data and adjusting batch effect, DEGs were identified. Single-Sample Gene Set Enrichment Analysis (ssGESA), Functional enrichment analyses based on Gene Ontology (GO) resource, Kyoto Encyclopedia of Genes and Genomes (KEGG) resource, ESTIMATE algorithm were carried out to analyze the difference between AF and SR.</p> <p><strong>Results:</strong> In total, 105 atrial samples from 3 studies were included in the analysis. Compared with SR, AF tissue had more CD8 T cells (P = 0.039) and Th2 cells (P = 0.016), and it had fewer Th17 cells (P = 0.008), Tgd (P < 0.001) and NK CD56dim cells (P = 0.047). The differences between the left and right atrium in AF and SR were analyzed. In AF atrium tissue, a total of 88 DGEs (26 up-regulated, 61 down-regulated) were obtained. The enrichment signaling pathways and biological functions of DGEs were predicted.</p> <p><strong>Conclusions:</strong> The differing immune infiltrating cells and DEGs in left and right atrium indicate that there are different mechanisms for development remodeling and inflammatory environment of AF within the left and right atrium.</p>
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.