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577 results for “Growth hormone”
Data from: Suppression of a plant hormone gibberellin reduces growth of invasive plants more than native plants
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Data from: Predation, metabolic priming and early life-history rearing environment affect the swimming capabilities of growth hormone transgenic rainbow trout
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Growth hormone pulses are differentially regulated by the circadian clock gene Bmal1
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Data from: Influence of a growth hormone transgene on the genetic architecture of growth-related traits: a comparative analysis between transgenic and wild-type coho salmon
Genetic engineering has been increasingly applied to many commercially important plant and animal species, generating phenotypic changes that are not observed in natural populations and creating genetic interactions that have not experienced natural selection. The degree to and way in which such human-induced genetic variation interacts with the rest of the genome is currently largely unknown. Integrating such information into ecological and risk assessment frameworks is crucial to understand the potential effects of genetically modified organisms in natural environments. Here, we performed QTL mapping to investigate the genetic architecture of growth-related traits in non-transgenic (NT) and growth hormone transgenic (T) coho salmon with large changes in growth and related physiology, with the aim of identifying how an inserted transgene might influence the opportunity for selection. These fish shared the same parental genetic background, thus allowing us to determine whether the same or different loci influence these traits within the two groups. The use of over 1700 loci, derived from Restriction site Associated DNA Sequencing, revealed that different genomic regions were linked with growth over time between the two groups. Additionally, the effect sizes of detected QTL appear to have been influenced by the transgene. Direct comparison of QTL between the T and NT fish during two size-matched periods identified little overlap in their location. Taken together, the results showed that the transgene altered the genetic basis of growth-related traits in this species. The study has important implications for effective conservation and management of wild populations experiencing introduction of transgenes. Evolutionary changes and their ecological consequences may occur at different rates and in different directions in NT versus T individuals in response to selection. Thus assessments of phenotypic change, and hence ecological risk, should be determined periodically to evaluate whether initial estimates made with founder strains remain valid.
Growth Hormone Secretagogue MK-0677 Effect on IGF-1 Levels in ESRD Patients
ClinicalTrials.gov study NCT00395291. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of TV-1106 in Growth Hormone-Deficient Adults
ClinicalTrials.gov study NCT02410343. IPD Sharing: Not stated. Countries: 7. Publications: 0.
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)
ClinicalTrials.gov study NCT00915954. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Safety, Tolerability and Efficacy Study of TransCon hGH in Children With Growth Hormone Deficiency
ClinicalTrials.gov study NCT03305016. IPD Sharing: Not stated. Countries: 4. Publications: 0.
A Safety, Pharmacokinetic and Pharmacodynamic Study of ACP-001 (TransCon hGH) in Adults With Growth Hormone Deficiency
ClinicalTrials.gov study NCT01247675. IPD Sharing: NO. Countries: 4. Publications: 0.
Growth Hormone Releasing Hormone (GHRH) Treatment for Age-Related Sleep Disturbances
ClinicalTrials.gov study NCT00000380. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Role of Endogenous Estrogen in Growth-Hormone Regulation in Postmenopausal Women
ClinicalTrials.gov study NCT01186796. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.
ClinicalTrials.gov study NCT00766038. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Growth Hormone and Bone in Obesity
ClinicalTrials.gov study NCT01724489. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Growth Hormone Treatment in Children With Hypophosphatemic Rickets
ClinicalTrials.gov study NCT02720770. IPD Sharing: NO. Countries: 0. Publications: 1.
Growth Hormone and Intrahepatic Lipid Content in Patients With Nonalcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT02217345. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Research of Intensive Treatment in Hormone Receptor<10% and Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer Patients With Positive Lymph Node Residual Disease After Neoadjuvant Chemoth
ClinicalTrials.gov study NCT03270007. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome
ClinicalTrials.gov study NCT00266656. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Growth Hormone in Assisted Reproductive Technology Clinical Outcome of Poor Responder
ClinicalTrials.gov study NCT03027843. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Growth Hormone Use in Adults With Prader-Willi Syndrome
ClinicalTrials.gov study NCT00444964. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Adults With Low Growth Hormone Who Survived Childhood Cancer Where Treatment Caused Low Bone Density
ClinicalTrials.gov study NCT00145704. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.