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235
datasets available to search
ShareScore release 0.9.0
Dataset results
235 results for “Inflammasome”
Stimulation of soluble guanylate cyclase exerts anti-inflammatory actions in the liver through a VASP/NF-kB/NLRP3 inflammasome circuit
GEO Series GSE154892. Mus musculus. 16 samples. Type: Expression profiling by array.
NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells [cell line Nalm6]
GEO Series GSE66400. Homo sapiens. 16 samples. Type: Expression profiling by array.
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease
GEO Series GSE273186. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation
GEO Series GSE248579. Homo sapiens. 30 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Transcriptomics of THP-1 EVs released after inflammasome or TLR stimulation
GEO Series GSE180708. Homo sapiens. 93 samples. Type: Expression profiling by array.
Fig. 4 in Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway
Fig. 4. The glucose consumption assay of compounds 1–20. The concentrations of these compounds were 50 μM, ROSI (50 μM) was the positive control. *p <0.05, **p <0.01, compared to PA treatment group.
House Dust Mite Induced Inflammasome Activation on Corticosteroid Resistance
ClinicalTrials.gov study NCT03307278. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs
ClinicalTrials.gov study NCT06351722. IPD Sharing: Not stated. Countries: 0. Publications: 0.
mRNA Expression Changes in Organotin-Driven NLRP3 Inflammasome Activation in Murine Bone Marrow Derived Macrophages
GEO Series GSE155126. Mus musculus. 9 samples. Type: Expression profiling by array.
Inhibition of NLRP1 Inflammasome Activation by Tyrosine Kinase Inhibitors Restores Erythropoiesis in Diamond-Blackfan Anemia Syndrome
GEO Series GSE300483. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
IRF8 regulates transcription of Naips for NLRC4 inflammasome activation
GEO Series GSE110452. Mus musculus. 4 samples. Type: Expression profiling by array.
The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue
GEO Series GSE36033. Mus musculus. 13 samples. Type: Expression profiling by array.
Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19
GEO Series GSE185658. Homo sapiens. 48 samples. Type: Expression profiling by array.
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
GEO Series GSE66461. Mus musculus. 8 samples. Type: Expression profiling by array.
NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells [HG-U133_Plus_2]
GEO Series GSE66705. Homo sapiens. 171 samples. Type: Expression profiling by array.
Effects of Space Flight on Inflammasome Activation in the Brain of Mice (Hippocampus; ECLIA)
Space exploration exposes astronauts to stressors that alter the immune response, rendering them vulnerable to infections and diseases. In this study, we aimed to determine the levels of inflammasome activation in the brains of mice that were housed in the International Space Station (ISS) for 37 days. C57BL/6 mice were launched to the ISS as part of NASA’s Rodent Research 1 Mission on SpaceX-4 CRS-4 Dragon cargo spacecraft from September 21st, 2014, to October 25th, 2014. Dissected mouse brains from that mission were analyzed by immunoblotting of inflammasome signaling proteins and Electrochemiluminescence Immunoassay (ECLIA) for inflammatory cytokine levels. Our data indicate decreased inflammasome activation in the brains of mice that were housed in the ISS for 37 days when compared to the brains of mice that were maintained on the ground, and in mice corresponding to the baseline group that were sacrificed at the time of launching of SpaceX-4. Moreover, we did not detect any significant changes in the expression levels of the pro-inflammatory cytokines TNF-alpha, IL-2, IFN-gamma, IL-5, IL-6, IL-12p70 and IL-10 between the ground control and the flight groups. Together, these studies suggest that spaceflight results in a decrease in the levels of innate immune signaling molecules that govern inflammasome signaling in the brain of mice. This dataset derives results from the ECLIA assay using brain tissue.
Effects of Space Flight on Inflammasome Activation in the Brain of Mice (Brain, Western Blot and ECLIA)
Space exploration exposes astronauts to stressors that alter the immune response, rendering them vulnerable to infections and diseases. In this study, we aimed to determine the levels of inflammasome activation in the brains of mice that were housed in the International Space Station (ISS) for 37 days. C57BL/6 mice were launched to the ISS as part of NASA’s Rodent Research 1 Mission on SpaceX-4 CRS-4 Dragon cargo spacecraft from September 21st, 2014, to October 25th, 2014. Dissected mouse brains from that mission were analyzed by immunoblotting of inflammasome signaling proteins and Electrochemiluminescence Immunoassay (ECLIA) for inflammatory cytokine levels. Our data indicate decreased inflammasome activation in the brains of mice that were housed in the ISS for 37 days when compared to the brains of mice that were maintained on the ground, and in mice corresponding to the baseline group that were sacrificed at the time of launching of SpaceX-4. Moreover, we did not detect any significant changes in the expression levels of the pro-inflammatory cytokines TNF-alpha, IL-2, IFN-gamma, IL-5, IL-6, IL-12p70 and IL-10 between the ground control and the flight groups. Together, these studies suggest that spaceflight results in a decrease in the levels of innate immune signaling molecules that govern inflammasome signaling in the brain of mice. This dataset derives results from the ECLIA and Western Blot assays using brain tissue.
Effects of Space Flight on Inflammasome Activation in the Brain of Mice (Cortex; ECLIA)
Space exploration exposes astronauts to stressors that alter the immune response, rendering them vulnerable to infections and diseases. In this study, we aimed to determine the levels of inflammasome activation in the brains of mice that were housed in the International Space Station (ISS) for 37 days. C57BL/6 mice were launched to the ISS as part of NASA’s Rodent Research 1 Mission on SpaceX-4 CRS-4 Dragon cargo spacecraft from September 21st, 2014, to October 25th, 2014. Dissected mouse brains from that mission were analyzed by immunoblotting of inflammasome signaling proteins and Electrochemiluminescence Immunoassay (ECLIA) for inflammatory cytokine levels. Our data indicate decreased inflammasome activation in the brains of mice that were housed in the ISS for 37 days when compared to the brains of mice that were maintained on the ground, and in mice corresponding to the baseline group that were sacrificed at the time of launching of SpaceX-4. Moreover, we did not detect any significant changes in the expression levels of the pro-inflammatory cytokines TNF-alpha, IL-2, IFN-gamma, IL-5, IL-6, IL-12p70 and IL-10 between the ground control and the flight groups. Together, these studies suggest that spaceflight results in a decrease in the levels of innate immune signaling molecules that govern inflammasome signaling in the brain of mice. This dataset derives results from the ECLIA assay using brain tissue.
RIPK3 negatively regulates the (CXCL4+TLR8)-induced IFN response while promoting NLRP3 inflammasome activation in human monocytes
GEO Series GSE201909. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury by suppressing the NLRP3 inflammasome
GEO Series GSE89311. Mus musculus. 8 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.