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Dataset results
640 results for “Peripheral neuropathy”
Effect of Ambroxol in Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT05558878. IPD Sharing: NO. Countries: 1. Publications: 30.
Data from: Impact of genetic reduction of NMNAT2 on chemotherapy-induced losses in cell viability in vitro and peripheral neuropathy in vivo
Nicotinamide mononucleotide adenylyl transferases (NMNATs) are essential neuronal maintenance factors postulated to preserve neuronal function and protect against axonal degeneration in various neurodegenerative disease states. We used in vitro and in vivo approaches to assess the impact of NMNAT2 reduction on cellular and physiological functions induced by treatment with a vinca alkaloid (vincristine) and a taxane-based (paclitaxel) chemotherapeutic agent. NMNAT2 null (NMNAT2-/-) mutant mice die at birth and cannot be used to probe functions of NMNAT2 in adult animals. Nonetheless, primary cortical cultures derived from NMNAT2-/- embryos showed reduced cell viability in response to either vincristine or paclitaxel treatment whereas those derived from NMNAT2 heterozygous (NMNAT2+/-) mice were preferentially sensitive to vincristine-induced degeneration. Adult NMNAT2+/- mice, which survive to adulthood, exhibited a 50% reduction of NMNAT2 protein levels in dorsal root ganglia relative to wildtype (WT) mice with no change in levels of other NMNAT isoforms (NMNAT1 or NMNAT3), NMNAT enzyme activity (i.e. NAD/NADH levels) or microtubule associated protein-2 (MAP2) or neurofilament protein levels. We therefore compared the impact of NMNAT2 knockdown on the development and maintenance of chemotherapy-induced peripheral neuropathy induced by vincristine and paclitaxel treatment using NMNAT2+/- and WT mice. NMNAT2+/- did not differ from WT mice in either the development or maintenance of either mechanical or cold allodynia induced by either vincristine or paclitaxel treatment. Intradermal injection of capsaicin, the pungent ingredient in hot chili peppers, produced equivalent hypersensitivity in NMNAT2+/- and WT mice receiving vehicle in lieu of paclitaxel. Capsaicin-evoked hypersensitivity was enhanced by prior paclitaxel treatment but did not differ in either NMNAT2+/- or WT mice. Thus, capsaicin failed to unmask differences in nociceptive behaviors in either paclitaxel-treated or paclitaxel-untreated NMNAT2+/- and WT mice. Moreover, no differences in motor behavior were detected between genotypes in the rotarod test. Our studies do not preclude the possibility that complete knockout of NMNAT2 in a conditional knockout animal could unmask a role for NMNAT2 in protection against detrimental effects of chemotherapeutic treatment.
A Study to Evaluate the Efficacy, Safety, and Tolerability of Tapentadol ER Compared With Placebo in Patients With Chronic, Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT01041859. IPD Sharing: Not stated. Countries: 3. Publications: 0.
A Post Market Cohort With the Spinal Modulation Neurostimulator System in Peripheral Neuropathy
ClinicalTrials.gov study NCT02349646. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
ClinicalTrials.gov study NCT05121558. IPD Sharing: YES. Countries: 1. Publications: 0.
Ricolinostat in Patients With Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT03176472. IPD Sharing: NO. Countries: 1. Publications: 0.
Acupuncture for Chemo-Induced Peripheral Neuropathy in Multiple Myeloma Patients
ClinicalTrials.gov study NCT04770402. IPD Sharing: NO. Countries: 1. Publications: 0.
MC5-A Scrambler Therapy in Reducing Peripheral Neuropathy Caused by Chemotherapy
ClinicalTrials.gov study NCT01290224. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of Gabapentin in Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT00712439. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Effect of Cocoa Supplementation Peripheral and Autonomic Diabetic Neuropathy
ClinicalTrials.gov study NCT05247034. IPD Sharing: Not stated. Countries: 1. Publications: 0.
1068GCC Evaluate Efficacy & Explore Mechanism of Acupuncture in Treating Bortezomib-induced Peripheral Neuropathy (BIPN) in Multiple Myeloma
ClinicalTrials.gov study NCT01541644. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Assess Safety and Efficacy of Engensis in Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT04469270. IPD Sharing: Not stated. Countries: 1. Publications: 0.
EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT05476276. IPD Sharing: NO. Countries: 1. Publications: 0.
Yiqi Wenjing Prescriptions Preventive Efficacy of Oxaliplatin-induced Peripheral Neuropathy Clinical Trial
ClinicalTrials.gov study NCT04690283. IPD Sharing: YES. Countries: 0. Publications: 1.
Effect of Transcranial Direct Current Stimulation on Peripheral Neuropathy
ClinicalTrials.gov study NCT03073759. IPD Sharing: NO. Countries: 1. Publications: 0.
MC-5A for Chemotherapy Induced Peripheral Neuropathy
ClinicalTrials.gov study NCT01261780. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of an Exercise Intervention on Taxane-induced Peripheral Neuropathy in Breast Cancer Survivors
ClinicalTrials.gov study NCT05641571. IPD Sharing: NO. Countries: 0. Publications: 1.
Voxx Human Performance Technology Socks for Chemotherapy-Induced Peripheral Neuropathy
ClinicalTrials.gov study NCT04403802. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy
ClinicalTrials.gov study NCT01480297. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Acupuncture to Prevent Chemotherapy Dose Reduction Due to Chemotherapy-induced Peripheral Neuropathy in Breast and Colorectal Cancer Patients (GCC1232)
ClinicalTrials.gov study NCT01881932. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.