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468 results for “Spikes”
Dynamic Tactility by Position-Encoded Spike Spectrum
<p>Title: Dynamic Tactility by Position-Encoded Spike Spectrum<br> Authors: Taeyeong Kim1, Jaehun Kim2, Insang You3, Joosung Oh1, Sung-Phil Kim2*, Unyong Jeong1*<br> Affiliations:<br> 1 Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea<br> 2 Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea<br> 3 Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea<br> *Corresponding authors: spkim@unist.ac.kr, ujeong@postech.ac.kr </p>
Inter-spike Intervals Data
<p>In this dataset you can find the inter-spike intervals experimental data recorded under sinusoidal modulation and a given Idc value for a semiconductor laser under optical feedback and current modulation. The DC pump current ranges from 25.5 to 27.5mA and the modulation amplitude from 40 to 100 (arb units) while the modulation frequency ranges from 1 to 80 MHz.</p>
Supplementary visualisations for "Chronic iEEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states"
<p>Supplementary file containing patient-specific visualisations of seizure network state progressions and interictal spike rate decompositions for "Chronic iEEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states."</p> <p>See preprint at https://arxiv.org/abs/2201.11600</p>
Impact of New Variants on SARS-CoV-2 Infectivity and Neutralization: A Molecular Assessment of the Alterations in the Spike-Host Protein Interactions
<p>MD simulation trajectories and structural models from the work which first appeared on bioRxiv (https://doi.org/10.1101/2021.01.10.426143), later ssrn (<a href="https://dx.doi.org/10.2139/ssrn.3907841">http://dx.doi.org/10.2139/ssrn.3907841</a>), and finally accepted for publication by Iscience.</p> <p>File Name: <a href="https://zenodo.org/api/files/d5ac679d-c267-4e55-8f63-0abdaa41d067/Run1_WT_RBD_ACE2.zip">Run1_WT_RBD_ACE2.zip</a></p> <p>Description: A compressed (zipped) folder contains three independent MD trajectories of WT RBD-ACE2 complex.</p> <p>File Name: <a href="https://zenodo.org/api/files/d5ac679d-c267-4e55-8f63-0abdaa41d067/Run2_N501Y_RBD_ACE2.zip">Run2_N501Y_RBD_ACE2.zip</a></p> <p>Description: A compressed folder contains three independent MD trajectories of Alpha RBD-ACE2 complex.</p> <p>File Name: <a href="https://zenodo.org/api/files/d5ac679d-c267-4e55-8f63-0abdaa41d067/Run3_Beta_RBD_ACE2.zip">Run3_Beta_RBD_ACE2.zip</a></p> <p>Description: A compressed folder contains three independent MD trajectories of Beta RBD-ACE2 complex.</p> <p>File Name: <a href="https://zenodo.org/api/files/d5ac679d-c267-4e55-8f63-0abdaa41d067/Run4_Delta_RBD_ACE2.zip">Run4_Delta_RBD_ACE2.zip</a></p> <p>Description: A compressed folder contains three independent MD trajectories of Delta RBD-ACE2 complex</p> <p>File Name: <a href="https://zenodo.org/api/files/d5ac679d-c267-4e55-8f63-0abdaa41d067/Run5_UK2_E484K_N501Y_ACE2.zip">Run5_UK2_E484K_N501Y_ACE2.zip</a></p> <p>Description: A compressed folder contains three independent MD trajectories of UK2 RBD-ACE2 complex</p> <p>File Name: <a href="https://zenodo.org/api/files/d5ac679d-c267-4e55-8f63-0abdaa41d067/Structural_model_PDBs.zip">Structural_model_PDBs.zip</a></p> <p>Description: A compressed folder contains eight pdb files of those structural models plotted in Figs 1, 3, 5, 6, 7 and S1.</p>
Inter-spike Intervals Data (Pulsed modulation)
<p>In this dataset you can find the inter-spike intervals experimental data recorded under sinusoidal modulation and a given Idc value for a semiconductor laser under optical feedback and current modulation. The DC pump current ranges from 25.5 to 27.5mA and the modulation amplitude is set constant to 100 (arb units) while the modulation frequency ranges from 1 to 70 MHz.</p>
Inter-spike Intervals Data for pulsed an dsinusoidal modulation
<p>In this dataset you can find the inter-spike intervals experimental data recorded under pulsed and sinusoidal modulation and a given Idc value for a semiconductor laser under optical feedback and current modulation. The DC pump current ranges from 25.5 to 27.5mA and the modulation amplitude from 30 to 100 (arb units) while the modulation frequency ranges from 1 to 80 MHz.</p>
Cleavage of SARS-CoV-2 spike protein mutants
<p class="MsoNormal"><span>Several SARS-CoV-2 variants emerged that harbor mutations in the surface unit of the viral spike (S) protein that enhance infectivity and transmissibility. Here, we analyzed whether ten naturally-occurring mutations found within the extended loop harboring the S1/S2 cleavage site of the S protein, a determinant of SARS-CoV-2 cell tropism and pathogenicity, impact S protein processing and function. None of the mutations increased but several decreased S protein cleavage at the S1/S2 site, including S686G and P681H, the latter of which is found in variants of concern B.1.1.7 (Alpha variant) and B.1.1.529 (Omicron variant). None of the mutations reduced ACE2 binding and cell-cell fusion although several modulated the efficiency of host cell entry. The effects of mutation S686G on viral entry were cell-type dependent and could be linked to the availability of cathepsin L for S protein activation. These results show that polymorphisms at the S1/S2 site can modulate S protein processing and host cell entry. </span></p>
Figure 15 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 15. Life restoration of Draconyx loureiroi, in the environment represented by Lourinhã Formation. Credit: Victor Carvalho, used with permission under CC BY NC 4.0 license.
Figure 13 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 13. Time calibrated Maximum Compatibility Tree (MCT) of the Bayesian clock analysis of the dataset of Xu et al. (2018). Colours of the branches reflect median evolutionary rates and number represents absolute values along branches themselves.
Figure 11 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 11. Pruned strict consensus tree of the parsimony analysis of the dataset of Bell et al. (2018). Bootstrap value in blue, Bremer support in red. Silhouettes from phylopic.org. Credit: Nobu Tamyra, Matthew Dempsey and Gareth Monger.
Figure 10 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 10. Comparison between the left femur ML 434 and the right femur SHN.(JJS).15. Femur SHN.015 and ML 434 in cranial (A, C) and medial (B, D) view. Abbreviations: 4th: fourth trochanter, cr, crest, fh, femoral head, lc, lateral condyle, lt, lesser trochanter, mc, medial condyle, mcl, scar of the Musculus caudifemoralis longus.
Figure 12 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 12. Time calibrated strict consensus tree of the analysis including Draconyx loureiroi in the dataset of Xu et al. (2018) (A). Bootstrap value in blue, Bremer support in red. Red colour is associated with an increasing Homoplasy Concentration index. XY graphs of Average Evolutionary Rates (B) and Average Homoplasy Rates (C) through time. Note the coinciding peaks of both AER and AHR. Silhouettes from phylopic.org. Credit: Michael Keesey, Matthew Dempsey and Pete Buchholz.
Figure 8 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 8. Three dimensional models of the pes of Draconyx loureiroi holotype ML 357. Articulated pes (ML 357-12) (A–F) in medial (A), lateral (B), dorsal (C), plantar (D) and caudal (E) views, F, detail of metatarsal I. Abbreviations: as: astragalus, ca, calcalneum, fi: fibula, lm: lateral malleolus, mm: medial malleolus, mt-I: metatarsal I, mt-II: metatarsal II, mt-III: metatarsal III, mt-IV: metatarsal IV, p II-1: pedal phalanx II-1, p II-1: pedal phalanx II-2, p III-1: pedal phalanx III-1, p III-3: pedal phalanx III-3, ta-3: tarsal 3, ta-4: tarsal 4, un-II: ungual II, un-III: ungual III.
Figure 6 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 6. Three dimensional models of limb bones elements of Draconyx loureiroi holotype ML 357 (ML 357 6-8), femur (A–E) and tibia and proximal end of fibula (F–J). Femur (ML 357 – 6) in cranial view (A), medial view (B), caudal view (C), lateral view (D) and distal view (E). Tibia (ML 357 – 7) and proximal end of fibula (ML 357 – 8) in cranial view (F), medial view (G), caudal view (H), lateral (I) and proximal (J) views.
Figure 1 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 1. Geographical and geological settings of ML 357. A, B, Stratigraphic log of the Lourinhã Formation and position of the specimen. C, Re-adapted from Rotatori et al. (2020). Map of the Iberian Peninsula courtesy of Eduardo Puertolas-Pascual.
Figure 7 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 7. Comparison of distal sections of femoral shaft from selected iguanodontians. A, Draconyx loureiroi, B, Uteodon aphanoecetes, C, Cumnoria prestwichii, D, Camptosaurus dispar, E, Barilium dawsoni, F, Mantellisaurus atherfieldensis and G, Iguanodon galvensis. Abbreviations: cod: condylid, eg: extensor groove, fg: flexor groove, lc: lateral condyle, mc: medial condyle. Distal sections drawn from: Carpenter & Wilson, 2008; Galton & Powell, 1980; Norman, 2011; Norman, 1986; Verdù et al., 2018.
Figure 2 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 2. Two maxillary teeth of Draconyx loureiroi holotype ML 357 in labial and lingual views. Completely preserved maxillary in labial (A) and lingual (C) views; isolated maxillary crown in labial (B) and lingual (D) views. Abbreviations: ne: neck, os: occlusal surface, pr: primary ridge, tr: tertiary ridges.
Figure 4 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 4. Three dimensional models of axial skeleton of Draconyx loureiroi holotype ML 357 (A–F): Caudal n.2 ML 357-10 in cranial view (A), left lateral view (B), caudal view (C), right lateral view (D), ventral view (E) and dorsal view (F). Caudal n.3 ML 357-11 (G–L) in cranial view (G), left lateral view (H), caudal view (I), right lateral view (J), ventral view (K) and dorsal view (L). Caudal n.1 ML 357-9 (M-R): cranial view (M), left lateral view (N), caudal view (O), right lateral view (P), ventral view (Q) and dorsal view (R). Abbreviations: cf: chevron facet, k: keel, nc: neural canal, ns: neural spine, tp: transverse process.
Figure 14 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 14. Comparison of the manual anatomy of selected styracosternans. Uteodon aphanoecetes left manus (specimen CM 11337) in extensor view (A), proximal view (D) and palmar view (G). Camptosaurus dispar right manus, reversed (specimen USNM 4277) in extensor view (B), proximal view (E) and palmar view (H) (holotype USNM 4282). Magnamanus soriaensis right manus (holotype MNS 2000) in extensor view (C), proximal view (F) and palmar view (I). Note the difference in the structure of the carpus: Uteodon aphanoecetes presents a partially fused and not closely packed carpus, Camptosaurus dispar presents a partially fused but closely packed carpus while Magnamanus soriaensis presents the typical stout and fused element of Styracosterna. J, Stratigraphic distribution of these characters. Abbreviations: dc1: distal carpal 1, dc2: distal carpal 2, dc3: distal carpal 3, dc4: distal carpal4, dc5: distal carpal 5, in: intermedium, mc1: metacarpal 1, ra: radiale, ul: ulnare.
Figure 9 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 9. Three dimensional models of the articulated leg (A–B) and pes (C–D) of Draconyx loureiroi holotype ML 357. Leg in medial view (A) and lateral view (B). Pes in medial (C) and lateral (D) views.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.