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329 results for “histopathology”
His-MMDM: Multi-domain and Multi-omics Translation of Histopathology Images with Diffusion Models
<p>part aa of HMU1st</p>
Figure 8 from: Fanelli E, Vovlas A, Santoro S, Troccoli A, Lucarelli G, Trisciuzzi N, De Luca F (2019) Integrative diagnosis, biological observations, and histopathology of the fig cyst nematode Heterodera fici Kirjanova (1954) associated with Ficus carica L. in southern Italy. ZooKeys 824: 1-19. https://doi.org/10.3897/zookeys.824.26820
Figure 8 Phylogenetic trees of the 18S rRNA gene of Heteroderafici and the closest species. Sequences were analysed using the Maximum Likelihood method. Numbers at nodes indicate bootstrap values.
Figure 7 from: Fanelli E, Vovlas A, Santoro S, Troccoli A, Lucarelli G, Trisciuzzi N, De Luca F (2019) Integrative diagnosis, biological observations, and histopathology of the fig cyst nematode Heterodera fici Kirjanova (1954) associated with Ficus carica L. in southern Italy. ZooKeys 824: 1-19. https://doi.org/10.3897/zookeys.824.26820
Figure 7 Phylogenetic trees of the D2–D3 expansion domains of the 28S rRNA gene of Heteroderafici and the closest species. Sequences were analysed using the Maximum Likelihood method. Numbers at nodes indicate bootstrap values.
Figure 2 from: Fanelli E, Vovlas A, Santoro S, Troccoli A, Lucarelli G, Trisciuzzi N, De Luca F (2019) Integrative diagnosis, biological observations, and histopathology of the fig cyst nematode Heterodera fici Kirjanova (1954) associated with Ficus carica L. in southern Italy. ZooKeys 824: 1-19. https://doi.org/10.3897/zookeys.824.26820
Figure 2 LM micrographs of Heteroderafici from Italy. A Embryonated egg with evident second stage juvenile stylet B Second stage juvenile anterior end C Second stage juvenile tail D Male tail with the characteristic tail tip E Females on Ficuscarica roots F whole body of newly formed cyst G Females and cysts H-J Vulval cone structures, with clear illustration of vulval slit (in H), fenestral area (in I) and bullae (in J). Scale bars: 20 µm (A-D, H-J); 200 µm (F); 500 µm (E, G).
Figure 5 from: Fanelli E, Vovlas A, Santoro S, Troccoli A, Lucarelli G, Trisciuzzi N, De Luca F (2019) Integrative diagnosis, biological observations, and histopathology of the fig cyst nematode Heterodera fici Kirjanova (1954) associated with Ficus carica L. in southern Italy. ZooKeys 824: 1-19. https://doi.org/10.3897/zookeys.824.26820
Figure 5 RFLP profiles of the ITS of Heteroderafici digested with four restriction enzymes. M 100 bp DNA ladder (Promega); 1 Alu I 2 Hae III 3 Rsa I 4 Pst I.
Figure 1 from: Fanelli E, Vovlas A, Santoro S, Troccoli A, Lucarelli G, Trisciuzzi N, De Luca F (2019) Integrative diagnosis, biological observations, and histopathology of the fig cyst nematode Heterodera fici Kirjanova (1954) associated with Ficus carica L. in southern Italy. ZooKeys 824: 1-19. https://doi.org/10.3897/zookeys.824.26820
Figure 1 Line drawings of Heteroderafici from Italy. A, B Anterior body portions of second stage juvenile C, D Second stage juvenile tail E Female anterior region F, G Cyst shape H Fenestral structures J, K Male tail, showing spicules and cloacal tube I Male pharyngeal region.
Figure 4 from: Fanelli E, Vovlas A, Santoro S, Troccoli A, Lucarelli G, Trisciuzzi N, De Luca F (2019) Integrative diagnosis, biological observations, and histopathology of the fig cyst nematode Heterodera fici Kirjanova (1954) associated with Ficus carica L. in southern Italy. ZooKeys 824: 1-19. https://doi.org/10.3897/zookeys.824.26820
Figure 4 Post invasion development of Heteroderafici on Ficuscarica roots. A Second stage juvenile within cortical layer, oriented in parallel position to the root axis B Newly formed cyst with gelatinous egg sac C Male inside 4th stage cuticle D Different sized syncytia (S) induced by female (the larger one), and by male. Abbreviations: j = juvenile; m = male; c = cyst; hn = hypertrophied nuclei. Scale bars: 50 µm (A, C); 200 µm (B); 100 µm (D).
Figure 6 from: Fanelli E, Vovlas A, Santoro S, Troccoli A, Lucarelli G, Trisciuzzi N, De Luca F (2019) Integrative diagnosis, biological observations, and histopathology of the fig cyst nematode Heterodera fici Kirjanova (1954) associated with Ficus carica L. in southern Italy. ZooKeys 824: 1-19. https://doi.org/10.3897/zookeys.824.26820
Figure 6 Phylogenetic trees of ITS containing region of Heteroderafici and the closest species. Sequences were analysed using the Maximum Likelihood method. Numbers at nodes indicate bootstrap values.
Figure 3 from: Fanelli E, Vovlas A, Santoro S, Troccoli A, Lucarelli G, Trisciuzzi N, De Luca F (2019) Integrative diagnosis, biological observations, and histopathology of the fig cyst nematode Heterodera fici Kirjanova (1954) associated with Ficus carica L. in southern Italy. ZooKeys 824: 1-19. https://doi.org/10.3897/zookeys.824.26820
Figure 3 SEM photographs of the main cyst diagnostic characters of Heteroderafici from Italy. A Female anterior end B Lateral view of terminal cone C, D Fenestral area and anus E Maze-like cyst cuticular ornamentation F Cyst anal area G Male lateral fields. Scale bars: 10 µm (A, G); 20 µm (B–F).
Figure 3 in Histopathological observations in Neogobius bathybius (Actinopterygii: Gobiidae) infected by Dichelyne minutus (Nematoda: Cucullanidae) in the Caspian Sea, Iran
Figure 3. Cross-sections of nonparasitized fish intestinal epithelium: a) normal arrangement of villi and structure of intestinal epithelium; b) normal feature of mucosa (m) and goblet cells (arrows) and c) normal blood vessels, muscular-arteries (arrowheads), and veins (arrows); d) normal distribution and number of goblet cells (arrows).
Figure 2 in Investigation of protective effects of lithium borate on spermatogenesis and testes histopathology against cadmium-induced acute toxicity in rats
Figure 2. In testicular tissue, control group, normal histological appearance (A), Cd group, severe hyperaemia (arrows) and haemorrhage (stars) in intertubular intervals, severe levels degenerative and necrotic changes in spermatocytes (arrowhead) (B), LTB group, normal histological appearance (C), LTB + Cd group, oedema in intertubular intervals (stars), mild degeneration of spermatocytes (arrows) (D), H&E, Bar: 20 µm.
ecPath: Predicting ecDNA status in Tumors from Histopathology Slide Images
Open the record for dataset details and reuse information.
Data from: Reporting tumor molecular heterogeneity in histopathological diagnosis
Background: Detection of molecular tumor heterogeneity has become of paramount importance with the advent of targeted therapies. Analysis for detection should be comprehensive, timely and based on routinely available tumor samples. Aim: To evaluate the diagnostic potential of targeted multigene next-generation sequencing (TM-NGS) in characterizing gastrointestinal cancer molecular heterogeneity. Methods: 35 gastrointestinal tract tumors, five of each intestinal type gastric carcinomas, pancreatic ductal adenocarcinomas, pancreatic intraductal papillary mucinous neoplasms, ampulla of Vater carcinomas, hepatocellular carcinomas, cholangiocarcinomas, pancreatic solid pseudopapillary tumors were assessed for mutations in 46 cancer-associated genes, using Ion Torrent semiconductor-based TM-NGS. One ampulla of Vater carcinoma cell line and one hepatic carcinosarcoma served to assess assay sensitivity. TP53, PIK3CA, KRAS, and BRAF mutations were validated by conventional Sanger sequencing. Results: TM-NGS yielded overlapping results on matched fresh-frozen and formalin-fixed paraffin-embedded (FFPE) tissues, with a mutation detection limit of 1% for fresh-frozen high molecular weight DNA and 2% for FFPE partially degraded DNA. At least one somatic mutation was observed in all tumors tested; multiple alterations were detected in 20/35 (57%) tumors. Seven cancers displayed significant differences in allelic frequencies for distinct mutations, indicating the presence of intratumor molecular heterogeneity; this was confirmed on selected samples by immunohistochemistry of p53 and Smad4, showing concordance with mutational analysis. Conclusions: TM-NGS is able to detect and quantitate multiple gene alterations from limited amounts of DNA, moving one step closer to a next-generation histopathologic diagnosis that integrates morphologic, immunophenotypic, and multigene mutational analysis on routinely processed tissues, essential for personalized cancer therapy.
Fig. 2 in Histopathology of gills, kidney and liver of a Neotropical fish caged in an urban stream
Fig. 2. Photomicrographs of the gill of P. lineatus caged in Cambé stream. a) normal aspect of the gill, showing the filament (gray arrow), the lamellae (L), the water channel (*), a pillar cell (black arrow) and an epithelial cell (arrowhead); b) lamellae with the marginal channel dilated (black arrow), hyperplasia of the epithelial cells (white arrow) and epithelial lifting (arrowheads); c) fusion of 3 lamellae (white arrow) and blood congestion (arrowhead); d) lamellar disorganization (arrowheads), partial fusion of some lamellae (white arrow) and hypertrophy of the lamellar epithelium (black arrow); e) lamellar aneurysm (white arrow) and epithelium rupture with hemorrhage (*). Scale bar 20mm, H.E.
A Dataset of Annotated Histopathological Images for Tumor Cellularity Assessment in Breast Cancer
<p>The dataset consists of 2 H&E whole slide images, captured at a magnification of 40×, which overall contains tens of thousands of tumor nuclei from patients with breast cancer. The annotations, which consist of tumor and non-tumor nuclei, were provided by an expert pathologist, using the QuPath software. In detail, within the indicated ROIs, 1419 tumor-nuclei and 605 non-tumor-nuclei were labeled for a total of 2024 nuclei (respectively 762 and 381 from the first WSI, 657 and 224 from the second WSI).</p> <p>The institutional Ethic Committee of the IRCCS Istituto Tumori Giovanni Paolo II approved the study -- Prot n. 8/CE (February 2, 2021).</p>
Contrastive learning-based histopathological feature infers molecular subtypes and clinical outcomes of breast cancer from unannotated whole slide images
<p>The breast cancer cohort came from the Changzhou Second People's Hospital (CZSPH) in Jiangsu, China. This cohort collected 91 FFPE WSIs from 90 breast cancer patients, including 15 recurrence cases within 5 years.</p>
DeepHP: A Gastric Mucosa Histopathology Image Collection for Helicobacter pylori Infection Diagnosis
<p>Precision medicine is benefiting from emerging deep learning-based applications, and one such application is computational histopathological analysis. However, a significant challenge arises from the scarcity of properly annotated training image datasets required for generating accurate classification and detection models. This scarcity primarily stems from human-related factors that hinder the acquisition of well-annotated data. To address this issue, the present study introduces DeepHP, a meticulously curated public collection of histopathological images. The DeepHP database encompasses a vast collection of 394,926 histopathological images, out of which 111k were annotated as Helicobacter pylori positive and 283k as Helicobacter pylori-negative.</p>
UTOM dataset: the dataset used for in silico histopathological staining
<p>UTOM dataset: the dataset used for in silico histopathological staining</p>
Copper Concentration & Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease Treated With ALXN1840
ClinicalTrials.gov study NCT04422431. IPD Sharing: NO. Countries: 8. Publications: 0.
A Comparative Evaluation of Different Histopathological Indices of Mucosal Healing in Ulcerative Colitis
ClinicalTrials.gov study NCT06918093. IPD Sharing: NO. Countries: 0. Publications: 8.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.