Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,108
datasets available to search
ShareScore release 0.9.0
Dataset results
1,108 results for “metabolome”
Plant diversity and soil legacy independently affect the plant metabolome and induced responses following herbivory
Open the record for dataset details and reuse information.
Targeted metabolomics data for riboflavin, FMN and FAD in <em>Mycobacteria tuberculosis</em> and <em>Mycolicibacterium smegmatis</em>
Open the record for dataset details and reuse information.
Transcriptomic and metabolomic analysis identifies potential targets of HADHA lactylation in LPS-treated H9c2 cells
Open the record for dataset details and reuse information.
Machine learning–enabled non–targeted metabolomics reveals nutritional and metabolic responses of <em>Brachypodium distachyon</em> to drought and elevated CO<sub>2</sub>
Open the record for dataset details and reuse information.
Local thermal environment and warming influence supercooling and drive widespread shifts in the metabolome of diapausing Pieris rapae butterflies
Open the record for dataset details and reuse information.
Data from: Metabolomic profiles of acute and chronic ambient hydrogen sulfide exposure in a mouse model
Open the record for dataset details and reuse information.
Lung proteome and metabolome endotype in HIV-associated obstructive lung disease
Open the record for dataset details and reuse information.
Data from: Single, but not dual, attack by a biotrophic pathogen and sap-sucking insect affects the oak leaf metabolome
Open the record for dataset details and reuse information.
Targeted metabolomics data for dimethyl-ribityl lumazine (DMRL) and riboflavin in Mycobacterium tuberculosis and Mycolicibacterium smegmatis mutants of the riboflavin biosynthetic pathway
Open the record for dataset details and reuse information.
Part 6: Kiss and spit metabolomics highlight the role of host purine metabolism during pathogen infection
Open the record for dataset details and reuse information.
Untargeted metabolomics molecular features data for plasma of 20 Peromyscus leucopus and 20 Mus musculus treated with LPS or controls
Open the record for dataset details and reuse information.
Pathway enrichments from untargeted metabolomics of plasma of Peromyscus leucopus and Mus musculus with or without LPS treatment
Open the record for dataset details and reuse information.
Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample specific ion distributions
<p>Data generated and analyzed in "Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample specific ion distributions"</p> <p>Boris Sarvin<sup>‡1</sup>, Shoval Lagziel<sup>‡2</sup>, Nikita Sarvin<sup>1</sup>, Dzmitry Mukha<sup>1</sup>, Praveen Kumar<sup>1</sup>, Elina Aizenshtein<sup>3</sup>, Tomer Shlomi *<sup>123</sup></p> <p><sup>1</sup> Faculty of Biology, Technion – Israel Institute of Technology, 32000 Haifa, Israel.</p> <p><sup>2</sup> Faculty of Computer Science, Technion – Israel Institute of Technology, 32000 Haifa, Israel.</p> <p><sup>3</sup> Lokey Center for Life Science and Engineering, Technion – Israel Institute of Technology, 32000 Haifa, Israel.</p> <p><sup>‡</sup> BS and SL contributed equally to this work.</p>
Untargeted LC–MS metabolomics reveals an adverse effect of high-fat diet on hepatic metabolism of Oreochromis niloticus
<p>Hepatic steatosis commonly occurs in intensively farmed tilapia. This disease is harmful to fish growth and health, but knowledge of the metabolic changes in tilapia with fatty liver is limited. In the present study, we compared genetically improved farmed tilapia (GIFT, <em>Oreochromis niloticus</em>) fed a high-fat diet (HFD) with those fed a normal-fat diet (NFD) for 8 weeks using LC-MS-based hepatic metabolomic assays and traditional nutritional assessments. Juvenile GIFT fed a HFD displayed higher fat disposition in the liver than did those fed a NFD. The metabolomic analyses revealed 61 differentially accumulated metabolites between the groups, and these metabolites were involved in 37 signaling pathways. Our results illustrate the development of metabolic disorders related to various hepatic biological processes, including protein metabolism, lipid metabolism, carbohydrate metabolism, and nucleotide metabolism in HFD-fed GIFT. These physiological changes may be related to the lower growth rate of GIFT. Overall, our study reveals the metabolic disorders in GIFT fed HFD, and enhance our knowledge of the mechanism of fatty liver formation in GIFT.</p>
Predicting human health from biofluid-based metabolomics using machine learning
<p>Processed input data sets as well as output files and trained health state predictive models for human diseases using metabolomics of biofluids. These data are associated with the following manuscript: 'Predicting human health from biofluid-based metabolomics using machine learning' https://doi.org/10.1101/2020.01.29.20019471</p>
Intracellular sodium elevation reprograms cardiac metabolism: Metabolomics data
<p><span><span><span><span><span><span><span><span><span><span><span>Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodeling occurs. We assessed whether acute (75μM ouabain 100nM blebbistatin) and chronic myocardial Na<sub>i</sub>load (PLM<sup>3SA </sup>mouse) are causally linked to metabolic remodeling and whether the hypertrophied failing heart shares a common Na-mediated metabolic 'fingerprint'. Control (PLM<sup>WT</sup>), transgenic (PLM<sup>3SA</sup>), ouabain treated and hypertrophied Langendorff-perfused mouse hearts were studied by <sup>23</sup>Na, <sup>31</sup>P, <sup>13</sup>C NMR followed by <sup>1</sup>H NMR metabolomic profiling. Elevated Na<sub>i</sub> leads to <i><u>common </u></i>adaptive metabolic alterations preceding energetic impairment: a switch from fatty acid to carbohydrate metabolism and changes in steady-state metabolite concentrations (glycolytic, anaplerotic, Krebs cycle intermediates). Inhibition of mitochondrial Na/Ca exchanger by CGP37157 ameliorated the metabolic changes. <i>In silico</i> modelling indicated altered metabolic fluxes (Krebs cycle, fatty acid, carbohydrate, amino acid metabolism). Prevention of Na<sub>i</sub> overload or inhibition of Na/Ca<sub>mito</sub>may be a new approach to ameliorate metabolic dysregulation in heart failure.</span></span></span></span></span></span></span></span></span></span></span></p>
Revealing Taxonomic and Diel Variation Through Untargeted Metabolomics
<p>A repository for the data and analysis used in B. Gordon's thesis, Chapter 6</p>
Data from: Metabolomics - Emory Cardiovascular Biobank
<p>Untargeted high-resolution plasma metabolomic profiling among patients with coronary artery disease. Patients recruited from the Emory Cardiovascular Biobank into independent discovery and validation cohorts. </p>
Supplementary data to accompany "Abundant metabolite-matrix adducts illuminate the dark metabolome of MALDI-mass-spectrometry imaging datasets"
<p>This dataset accompanies the publication "Abundant metabolite-matrix adducts illuminate the dark metabolome of MALDI-mass-spectrometry imaging datasets". The dataset includes all files, scripts and results that are included in the associated publication.</p> <p>Spatial metabolomics using mass spectrometry imaging (MSI) is a powerful tool to map hundreds or thousands of metabolites across biological systems. One major challenge is the complexity of the data, which includes signals from experimental artifacts. Formation of adducts (<em>e.g. </em>with Na+or K+) or abundant matrix-cluster, in the case of matrix-assisted laser desorption ionization (MALDI)-MSI, strongly increase peak counts. We developed <em>mass2adduct</em>, a universally applicable tool for adduct abundance estimations in high-mass-resolution spatial metabolomics datasets. Our study illustrates that MALDI-MSI data density is remarkably driven by adduct formation and revealed a major influence of so far unrecognized metabolite-matrix adducts on total peak counts. Current data analyses neglect those matrix adducts and therefore overestimate total metabolite numbers, thereby inflating the dark metabolome size.</p> <p>mass2adduct zenodo doi (10.5281/zenodo.1405088)</p> <p>mass2adduct gihub: https://github.com/kbseah/mass2adduct</p>
Metabolomics dataset to identify plasma biomarkers in mice with metabolically heterogeneous melanoma xenografts
<p>Tumor xenografts were generated in mice using BRAF mutant A375 and WM47, NRAS mutant WM3000, and WM3311 (BRAF, NRAS, NF-1 wildtype) human melanoma cells. Xenograft tumor and plasma samples obtained from melanoma-bearing and non-tumor mice were analyzed using the MxP® Quant 500 kit in combination with the inhouse UHPLC-MS/MS-based acylcarnitine assay from Biocrates Life Sciences AG, Innsbruck, Austria. The data were used to characterize the metabolomes of human melanoma cell lines with different genetic background transplanted into mice in order to identify potential new biomarkers and targets for melanoma therapy.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.