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1,145 results for “somatic”
COMPARATIVE ANALYSIS OF SOMATIC PHRASEOLOGY IN ENGLISH AND KARAKALPAK LANGUAGES
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Data from: Genome-wide inference of somatic translocation events during potato dihaploid production
Potato (Solanum tuberosum L.) breeders often use dihaploids, which are 2× progeny derived from 4× autotetraploid parents. Dihaploids can be used in diploid crosses to introduce new genetic material into breeding germplasm that can be integrated into tetraploid breeding through the use of unreduced gametes in 4× by 2× crosses. Dihaploid potatoes are usually produced via pollination by haploid inducer lines known as in vitro pollinators (IVP). In vitro pollinator chromosomes are selectively degraded from initially full hybrid embryos, resulting in 2× seed. During this process, somatic translocation of IVP DNA may occur. In this study, a genome-wide approach was used to identify such events and other chromosome-scale abnormalities in a population of 95 dihaploids derived from a cross between potato cultivar Superior and the haploid inducing line IVP101. Most Superior dihaploids showed translocation rates of <1% at 16,947,718 assayable sites, yet two dihaploids showed translocation rates of 1.86 and 1.60%. Allelic ratios at translocation sites suggested that most translocations occurred in individual cell lineages and were thus not present in all cells of the adult plants. Translocations were enriched in sites associated with high gene expression and H3K4 dimethylation and H4K5 acetylation, suggesting that they tend to occur in regions of open chromatin. The translocations likely result as a consequence of double-stranded break repair in the dihaploid genomes via homologous recombination during which IVP chromosomes are used as templates. Additionally, primary trisomy was observed in eight individuals. As the trisomic chromosomes were derived from Superior, meiotic nondisjunction may be common in potato.
Data from: Resolving the prevalence of somatic transposition in Drosophila
Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline. To understand the impact of transposition in somatic cells it is essential to reliably measure the frequency and map locations of new insertions. Here we identified thousands of putative somatic transposon insertions in neurons from individual Drosophila melanogaster using whole-genome sequencing. However, the number of de novo insertions did not correlate with transposon expression or fly age. Analysing our data with exons as "immobile genetic elements" revealed a similar frequency of unexpected exon translocations. A new sequencing strategy that recovers transposon : chromosome junction information revealed most putative de novo transposon and exon insertions likely result from unavoidable chimeric artefacts. Reanalysis of other published data suggests similar artefacts are often mistaken for genuine somatic transposition. We conclude that somatic transposition is less prevalent in Drosophila than previously envisaged.
Somatic Mindfulness Training for a Healthy Workforce: Student Pilot Sample
ClinicalTrials.gov study NCT04122534. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Liquid Biopsies for the Detection of Somatic Mutations in bAVMs
ClinicalTrials.gov study NCT06494358. IPD Sharing: YES. Countries: 1. Publications: 0.
CLARA: Somatic and Germline Mechanisms That Impact Renal Cancer Immunotherapy
ClinicalTrials.gov study NCT05215470. IPD Sharing: YES. Countries: 1. Publications: 0.
Assessment of Somatic Symptom in Chinese Community-Dwelling People
ClinicalTrials.gov study NCT04815863. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Binimetinib and Encorafenib for the Treatment of Pancreatic Cancer in Patients With a Somatic BRAF V600E Mutation
ClinicalTrials.gov study NCT04390243. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Rituximab in Combination With Fludarabine and Cyclophosphamide in Participants With Chronic Lymphocytic Leukemia and Favorable Somatic Status
ClinicalTrials.gov study NCT01271010. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Participants With Chronic Lymphocytic Leukemia and Unfavorable Somatic Status
ClinicalTrials.gov study NCT01283386. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Niraparib and Dostarlimab for the Treatment of Germline or Somatic BRCA1/2 and PALB2 Mutated Metastatic Pancreatic Cancer
ClinicalTrials.gov study NCT04493060. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial
ClinicalTrials.gov study NCT03990896. IPD Sharing: YES. Countries: 1. Publications: 0.
Welfare Benefits in Functional Somatic Disorders
ClinicalTrials.gov study NCT05611606. IPD Sharing: NO. Countries: 0. Publications: 1.
Programme of Acromegaly Screening in Patients With Associated Somatic Disorders
ClinicalTrials.gov study NCT02020967. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Analysis of structural and somatic variation in Mexican lime
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Data from: Experimental demonstration of the benefits of somatic fusion and the consequences for allorecognition
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Data from: Regular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in Neurospora
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Data from: Adrenalectomy completely cured hypertension in familial hyperaldosteronism type I patients with somatic KCNJ5 mutation
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Data from: Density regulation in Northeast Atlantic fish populations: density dependence is stronger in recruitment than in somatic growth
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Data from: Resolving the prevalence of somatic transposition in Drosophila
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.