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1,986 results for “valve”
Dysregulated microRNAs in calcific aortic valve disease
GEO Series GSE87885. Homo sapiens. 5 samples. Type: Non-coding RNA profiling by array.
Data set from Adamo M, Grasso C, Capodanno D, Rubbio AP, Scandura S, Giannini C, Fiorelli F, Fiorina C, Branca L, Brambilla N, Bedogni F, Petronio AS, Curello S, Tamburino C. Five-year clinical outcomes after percutaneous edge-to-edge mitral valve repair: Insights from the multicenter GRASP-IT registry. Am Heart J. 2019 Nov;217:32-41. doi: 10.1016/j.ahj.2019.06.015. Epub 2019 Jul 3. PMID: 31473325.
<p>Data set from Adamo M, Grasso C, Capodanno D, Rubbio AP, Scandura S, Giannini C, Fiorelli F, Fiorina C, Branca L, Brambilla N, Bedogni F, Petronio AS, Curello S, Tamburino C. Five-year clinical outcomes after percutaneous edge-to-edge mitral valve repair: Insights from the multicenter GRASP-IT registry. Am Heart J. 2019 Nov;217:32-41. doi: 10.1016/j.ahj.2019.06.015. Epub 2019 Jul 3. PMID: 31473325.</p> <p> </p> <p>This is the abstract:</p> <p>Limited evidence is available on 5-year clinical outcomes after percutaneous edge-to-edge mitral valve repair.</p> <p><strong>Methods: </strong>The Getting Reduction of mitrAl inSufficiency by Percutaneous clip implantation in ITaly (GRASP-IT) is a multicenter registry including 304 consecutive patients undergoing Mitraclip between October 2008 and October 2013 at 4 Italian centers. Primary end point (all-cause mortality) and secondary end point (all-cause mortality or heart failure [HF] hospitalization) were evaluated up to 5 years and between 1 and 5 years.</p> <p><strong>Results: </strong>Cumulative incidence of the primary and secondary end points at 1, 2, 3, 4, and 5 years were 15.1%, 26.4%, 35.5%, 42.1%, and 47.3% and 29.1%, 41.7%, 49.8%, 56%, and 62.3%, respectively. Landmark analysis between 1 and 5 years showed an incidence of primary and secondary end point of 37.9% and 46.8%, respectively. Five-year event rates were significantly higher in patients with functional ischemic mitral regurgitation (MR) compared to other etiologies. MR recurrence and left ventricular ejection fraction <30% were associated with an increased risk of both primary and secondary end points. EuroSCORE II >5% was associated with an increased risk of 5-year mortality. Ischemic etiology of MR, baseline serum creatinine >1.5 mg/dL, chronic obstructive pulmonary disease, and previous HF hospitalizations were independent predictors of 5-year secondary end point.</p> <p><strong>Conclusions: </strong>At 5-year follow-up after Mitraclip, nearly half of patients died and almost two thirds died or were admitted for HF. MR recurrence, ischemic etiology, high comorbidity burden (ie, EuroSCORE II >5%, chronic obstructive pulmonary disease), and advanced cardiomyopathy (ie, left ventricular ejection fraction <30%, prior HF admission, creatinine >1.5 mg/dL) significantly increase the relative risk of 5-year clinical events.</p>
Data set from Gorla R, De Marco F, Morganti S, Finotello A, Brambilla N, Testa L, Agnifili ML, Tusa M, Auricchio F, Bedogni F. Transcatheter aortic valve implantation with the Portico and Evolut R bioprostheses in patients with elliptic aortic annulus. EuroIntervention. 2020 Apr 3;15(18):e1588-e1591. doi: 10.4244/EIJ-D-19-00115. PMID: 31186219.
<p>Data set from Gorla R, De Marco F, Morganti S, Finotello A, Brambilla N, Testa L, Agnifili ML, Tusa M, Auricchio F, Bedogni F. Transcatheter aortic valve implantation with the Portico and Evolut R bioprostheses in patients with elliptic aortic annulus. EuroIntervention. 2020 Apr 3;15(18):e1588-e1591. doi: 10.4244/EIJ-D-19-00115. PMID: 31186219.</p> <p> </p><p> </p> <p></p>
Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients
<p>This record contains raw data related to the article “Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients”<strong>Background:</strong> Current knowledge regarding the relationship between aortic valve sclerosis (AVSc), cardiovascular risk factors, and mortality in patients with known coronary artery disease (CAD) is still unclear. The present study aimed at investigating the prevalence of AVSc as well as its association with long-term all-cause mortality in high-risk CAD patients that has never been explored in large cohorts thus far. <strong>Methods and Results:</strong> In this retrospective and observational cohort study we enrolled high-risk CAD patients, hospitalized at Centro Cardiologico Monzino (CCM), Milan, Italy, between January 2006 and December 2016. The morphology and function of the aortic valve were assessed from the recorded echocardiographic images to evaluate the presence of AVSc, defined as a non-uniform thickening of the aortic leaflets with no consequences on hemodynamics. Data on 5-year all-cause mortality was retrieved from a Regional database. Of the 5,489 patients initially screened, 4,938 (mean age 67 ± 11 years, 3,954 [80%] men) were enrolled in the study. In the overall population, AVSc was detected in 2,138 (43%) patients. Multivariable LASSO regression revealed that age, female gender, diabetes mellitus, previous MI, and left ventricular ejection fraction were independently associated with AVSc. All-cause mortality (adjusted hazard ratio: 1.29, 95%CI: 1.05-1.58) was significantly higher in AVSc than in non-AVSc patients. <strong>Conclusions:</strong> AVSc is frequently detected in high-risk CAD patients and is associated with long-term mortality. Our findings corroborate the hypothesis that AVSc is an underestimated marker of systemic cardiovascular risk. Thus, AVSc detection may be used to improve long-term risk stratification of high-risk CAD patients.</p>
3D Reconstruction of a Calcified Aortic Valve Cusp Based on Micro-Computed Tomography.
<p>Video showing 3D reconstruction of a calcified aortic valve cusp based on micro-computed tomography.</p>
Influence of chest conformation on myocardial strain parameters in healthy subjects with mitral valve prolapse
<p>Raw data.</p> <p>Abstract<br> Chest shape might affect myocardial strain parameters. However, the relationship between myocardial strain parameters and<br> chest conformation has not been previously investigated in subjects with mitral valve prolapse (MVP). Between April 2019<br> and May 2020, 60 healthy subjects (50.1 ± 8.6 year/old, 46.6% females) with MVP and mild-to-moderate mitral regurgitation,<br> and 60 controls matched by age, sex, and cardiovascular risk factors were consecutively studied. Participants underwent<br> modified Haller index (MHI) assessment (ratio of chest transverse diameter over the distance between sternum and spine),<br> and transthoracic echocardiography implemented with 2D-speckle tracking analysis. MHI was significantly greater in MVP<br> group than controls (2.6 ± 0.35 vs 2.1 ± 0.23, p < 0.0001). Left ventricular (LV) ejection fraction was similar in MVP and<br> controls (63.5 ± 3.7% vs 64.3 ± 3.9%, p = 0.25). LV regional and global longitudinal (GLS), circumferential (GCS) and radial<br> strain (GRS) parameters and LV peak twist were all significantly lower in MVP compared to controls (all p < 0.0001). MVP<br> subjects with a tight chest (MHI > 2.5, n = 30), and those with MHI ≤ 2.5 (n = 30) were then separately analyzed. A significant<br> impairment in myocardial strain parameters and LV peak twist was documented in MVP subjects with MHI > 2.5, but not in<br> those with MHI ≤ 2.5. MHI showed a strong inverse correlation with LV-GLS (r = − 0.85), GCS (r = − 0.84), GRS (r = − 0.84)<br> and LV peak twist (r = − 0.94). In MVP subjects, impairment of myocardial strain parameters is not due to intrinsic reduction<br> of cardiac contractility function, but it appears to be related to the degree of chest deformity.</p>
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