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2,009 results for “Disruption”
AAV vector-derived elements integrate into Cas9-generated double strand breaks and disrupt gene transcription
GEO Series GSE271068. Mus musculus. 60 samples. Type: Other.
The histone H3G34R mutation disrupts the epigenome via catalytic inactivation of the ASH1 H3K36 methyltransferase [ChIP-seq]
GEO Series GSE134449. Neurospora crassa. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds
GEO Series GSE202953. Homo sapiens. 36 samples. Type: Expression profiling by array.
Disruption of the Circadian Rhythm Is Exacerbated by Aging and Partially Restored by Time-restricted Feeding
GEO Series GSE264350. Mus musculus. 78 samples. Type: Expression profiling by high throughput sequencing.
CRISPRi Screening of Enhancers in Human Primary Astrocytes Identifies Regulatory Circuitry Disrupted in Alzheimer’s Disease
GEO Series GSE272121. Homo sapiens. 1 samples. Type: SNP genotyping by SNP array.
data set related to article Parenting practices moderate the link between attention to the eyes and callous unemotional traits in children with Disruptive Behavior Disorder: An eye-tracking study
<p>This record contains raw data related to article Parenting practices moderate the link between attention to the eyes and callous unemotional traits in children with Disruptive Behavior Disorder: An eye-tracking study</p>
Dataset associated with the paper "Thyroid Cancer and Endocrine Disruptive Chemicals: A Case-Control Study on Per-fluoroalkyl Substances (PFAS) and Other Persistent Organic Pollutants (POPs)"
<h2>Abstract</h2> <div> <p><strong>Objective: </strong>To evaluate the possible association between some endocrine disruptive chemicals and thyroid cancer (TC) in an Italian case-control cohort.</p> <p><strong>Methods: </strong>We enrolled 112 TC patients and 112 sex- and age-matched controls without known thyroid diseases. Per- and poly-fluoroalkyl substances (PFAS), poly-chlorinated biphenyls (PCBs), and dichlorodiphenyltrichloroethane (4,4'-DDT, and 4,4'-DDE) were measured in the serum by liquid or gas chromatography-mass spectrometry. Unconditional logistic regression, Bayesan Kernel Machine Regression and Weighted Quantile Sum models were used to estimate the association between TC and pollutants' levels, considered individually or as mixture. BRAFV600E mutation was assessed by standard methods.</p> <p><strong>Results: </strong>The detection of perfluorodecanoic acid (PFDA) was positively correlated to TC (OR= 2.03, 95% CI 1.10-3.75, p=0.02), while a negative association was found with perfluorohexanesulfonic acid (PFHxS) levels (OR=0.63, 95% CI 0.41-0.98, p=0.04). Moreover, perfluorononanoic acid (PFNA) was positively associated with the presence of thyroiditis, while PFHxS and perfluorooctane sulfonic acid (PFOS) with higher levels of pre-surgical Thyroid-Stimulating Hormone (TSH). PFHxS, PFOS, PFNA and PFDA were correlated with less aggressive TC, while poly-chlorinated biphenyls (PCB-105 and PCB-118) with larger and more aggressive tumours. Statistical models showed a negative association between pollutants' mixture and TC. BRAFV600E mutations resulted associated with PCB-153, PCB-138 and PCB-180.</p> <p><strong>Conclusions: </strong>Our study suggests, for the first time in a case-control population, that exposure to some PFAS and PCBs associates with TC and some clinical and molecular features. On the contrary, an inverse correlation was found with both PFHxS and pollutants' mixture, likely due to a potential reverse causality.</p> <p> </p> <p>Dataset associated with the paper "Thyroid Cancer and Endocrine Disruptive Chemicals: A Case-Control Study on Per-fluoroalkyl Substances (PFAS) and Other Persistent Organic Pollutants (POPs)".</p> <p>This set of raw data cannot be publicly available as including sensitive information, but might be made available to interested researchers upon reasonable request. Please, forward you request to l.fugazzola@auxologico.it</p> </div>
Giardia hinders growth by disrupting nutrient metabolism independent of inflammatory enteropathy
<p>NMR Data used in the manuscript</p>
16p11.2 copy number variants drive convergent cell-type specific disruptions in corticogenesis
GEO Series GSE293426. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.