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15,733 results for “article”
Dataset related to the article "S-Thiolation targets albumin in heart failure"
<p>This record contains raw data related to the article "S-Thiolation targets albumin in heart failure"</p> <p><strong>Abstract. </strong>Human serum albumin (HSA) is associated with several physiological functions, such as maintaining oncotic pressure and microvascular integrity, among others. It also represents the major and predominant antioxidant in plasma due to the presence of the Cys34 sulfhydryl group. In this study we assessed qualitative and quantitative changes in HSA in patients with heart failure (HF) and their relationship with the severity of the disease. We detected by means of mass spectrometry a global decrease of HSA content in the plasma of HF patients in respect to control subjects, a significant increase of thio-HSA with a concomitant decrease in the reduced form of albumin. Cysteine and, at lesser extent homocysteine, represent the most abundant thiol bound to HSA. A strong inverse correlation was also observed between cysteine-HSA and peak VO<sub>2</sub>/Kg, an index of oxygen consumption associated with HF severity. Moreover, in HL-1 cardiomyocytes incubated with H<sub>2</sub>O<sub>2</sub>, we showed a significant decrease of cell viability in cells treated with thio-HSA in respect to restored native-HSA. In conclusion, we found for the first time that S-thiolation of albumin is increased in the plasma of HF patients and induced changes in the structure and antioxidant function of HSA, likely contributing to HF progression.</p>
Data for the article titled "Multi-omics analysis characterizes the spatial architecture of glioblastoma ecosystems"
<p>Data archive for the article titled "Multi-omics analysis characterizes the spatial architecture of glioblastoma ecosystems"</p>
Synthetic Datasets from the Article titled Privacy-preserving Ground-truth Data for Evaluating Additive Feature Attribution in Regression Models with Additive CBR and CQV
<p>Synthetic datasets were generated as benchmarks capturing the intrinsic characteristics of original data to investigate the performance of additive feature attribution methods for regression tasks. The synthetic datasets were generated based on 2, 6 and 8 clusters formed with the original data. The 6-cluster dataset was used for primary analysis and the other two were used for sensitivity analysis.</p><p>The synthetic dataset was generated from the original data acquired from <a href="https://www.eurocontrol.int/dashboard/rnd-data-archive">Aviation Data for Research Repository</a>, which was collected and processed by <a href="https://www.eurocontrol.int/">EUROCONTROL</a> from the Enhanced Tactical Flow Management System (ETFMS) flight data messages containing all flights in Europe throughout the year 2019, from May to October. The original dataset consisted of fundamental details of the flights, flight status, preceding flight legs, ATFM regulations, weather conditions, calendar information, etc. </p><p>A brief description of the columns in the synthetic data files is presented in the file 'data_description.pdf' and a more detailed discussion on features can be found in the works of Koolen and Coliban [1] and Dalmau et al. [2].</p><p> </p><p><strong>References</strong><br>[1] H. Koolen and I. Coliban, <a href="https://www.eurocontrol.int/sites/default/files/2020-06/flight-progress-msg-update-230620.pdf">Flight Progress Messages Document</a>, EUROCONTROL, Brussels, Belgium, Tech. Rep., 2020.<br>[2] R. Dalmau, F. Ballerini, H. Naessens, S. Belkoura, and S. Wangnick, <a href="https://www.sciencedirect.com/science/article/pii/S0969699721000739">An Explainable Machine Learning Approach to Improve Take-off Time Predictions</a>, Journal of Air Transport Management, vol. 95, p. 102 090, Aug. 2021. doi: 10.1016/j.jairtraman.2021.102090.</p><p><br> </p>
Dataset related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center"
<p>This record contains raw data related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center"</p><p><strong>Abstract</strong></p><p><strong>Introduction:</strong> The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high-volume single center.</p><p><strong>Methods</strong>: Demographic, clinicopathological data on the diagnosis, treatment and follow-up of all sarcoma patients aged 16-39 years (ys) observed at our Institute between January 2010 and December 2021 were retrospectively collected, including diagnostic (TTD) and treatment delay(TTT), clinical outcomes (OS and PFS), and late-treatment effects.</p><p><strong>Results:</strong> We identified 228 AYA patients, median age 30 years, 29% ≤ 25 years, 57% males, 88% soft tissue sarcomas (STS), and 12% bone sarcomas (BS). Among STSs, 13% were small round cell tumors (SRCT), 52% intermediate-high-grade, 24% low-grade STSs. Among BS, 32% were high-grade. Median TTD and TTT were 120 (0-8255) and 7 days (0-83), respectively. Surgery was performed in 83%, radiotherapy in 29%, and systemic therapy in 27%. Median follow-up was 72.9 months(1.6-145), 5-year and 10-year OS were 78.5% and 62%, respectively. Kaplan-Meyer analysis showed a significantly better 5-year OS and PFS for patients with >92 days of TTD (OS 85.7% vs. 66.7%, p = 0.001, PFS 50.2% vs. 24.9%, p = 0.009). According to age (≤25 years vs. > 25 years), 5-year OS was 69.8% versus 82.2%, respectively (p = 0.047).</p><p><strong>Conclusion:</strong> Our analysis confirmed previous data on sarcoma AYA patients followed in a referral center. Unexpectedly, diagnostic delay was not associated with poor OS and PFS. Patients <25 years showed a poorer prognosis due to the higher incidence of SRCT.</p><p> </p>
Dataset related to the article "Outcomes of Transcatheter Aortic Valve Replacement Patients With Different Transvalvular Flow-gradient Patterns"
<p>This record contains raw data related to the article "Outcomes of Transcatheter Aortic Valve Replacement Patients With Different Transvalvular Flow-gradient Patterns".</p><p>Low-flow low-gradient (LF-LG) aortic stenosis (AS) may occur with preserved or depressed left ventricular ejection fraction (LVEF). Both situations represent the most challenging subset of patients to manage and generally have a poor prognosis. Few and controversial data exist on the outcomes of these patients compared to normal-flow high-gradient (NF-HG) AS following transcatheter aortic valve replacement (TAVR). We sought to characterize different transvalvular flow-gradient patterns and to examine their prognostic value after TAVR. We enrolled 1208 patients with severe AS and categorized as follow: 976 patients NF-HG (mean aortic pressure gradient, MPG≥40mmHg), 107 paradoxical cLF-LG (pLF-LG, MPG<40mmHg, LVEF≥50%, stroke volume index, SVi<35mL/m2), and 125 cLF-LG (MPG<40mmHg, LVEF<50%, SVi<35mL/m2). When compared with NF-HG and pLF-LG, cLF-LG had a worse symptomatic status (NYHA III-IV 86% vs 62% and 67%, p<0.001), a higher prevalence of eccentric hypertrophy and a higher level of LV global afterload reflected by a higher valvuloarterial impedance. Valvular function after TAVR was excellent over time in all patients. While 30-day mortality (p=0.911) did not differ significantly among groups, cLF-LG had a lower 5-year survival rate (LF-LG 50% vs pLF-LG 62% and NF-HG 68%, p<0.05). cLF-LG was associated with a hazard ratio for mortality of 2.41 (95% CI: 1.65-3.52, p<0.001). In conclusion, TAVR is an effective procedure regardless of transvalvular flow-gradient patterns. However, special care should be given to characterized hemodynamic of AS, as patients with pLF-LG had similar survival rates than patients with NF-HG, whereas cLF-LG is associated with a 2-fold increased risk of mortality at 5-year follow-up.</p>
Dataset related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis"
<p>This record contains raw data related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis"</p><p><strong>Abstract</strong></p><p><strong>Background: </strong>Aortic valve sclerosis (AVSc) presents similar pathogenetic mechanisms to coronary artery disease (CAD) and is associated with short- and long-term mortality in CAD patients. Evidence of AVSc-specific pathophysiological traits in acute myocardial infarction (AMI) is currently lacking. Thus, we aimed to identify a blood-based transcriptional signature that could differentiate AVSc from non-AVSc patients during AMI.</p><p><strong>Methods: </strong>Whole-blood transcriptome of AVSc (n = 44) and no-AVSc (n = 66) patients with AMI was assessed by RNA-sequencing on hospital admission. Feature selection, differential expression, and enrichment analyses were performed to identify gene expression patterns discriminating AVSc from no-AVSc and infer functional associations. Multivariable Cox regression analysis was used to estimate the hazard ratios of cardiovascular events in AVSc versus no-AVSc patients.</p><p><strong>Results:</strong> This cross-sectional study identified a panel of 100 informative genes capable of distinguishing AVSc from no-AVSc patients with 94% accuracy. Further analysis revealed significant mean differences in 143 genes, of which 30 genes withstood correction for age and previous AMI or coronary interventions. Functional inference unveiled a significant association between AVSc and key biological processes, including acute inflammatory responses, type I interferons (IFN) response, platelet activation, and hemostasis. Notably, AMI patients with AVSc exhibited a significantly higher incidence of adverse cardiovascular events during a 10-year follow-up period, with a full adjusted hazard ratio of 2.4 (95% CI 1.3–4.5).</p><p><strong>Conclusions:</strong> Our findings shed light on the molecular mechanisms underlying AVSc and provide potential prognostic insights for AMI patients with AVSc. During AMI, AVSc patients showed increased type I IFN response and earlier adverse cardiovascular outcomes. Novel pharmacological therapies aiming at limiting type I IFN response during or immediately after AMI might improve poor cardiovascular outcomes of AMI patients with AVSc.</p><p><strong>Keywords:</strong></p><p> Aortic valve sclerosis; acute myocardial infarction; immune response; inflammation; cardiovascular adverse events; risk stratification.</p>
Supporting data for the article M. Grześkowiak (2023), 'When Legal Inclusion is not Enough: the "Uganda Model" of Refugee Protection on the Brink of Failure', Refugee Survey Quarterly
<p>The set contains transcripts of in-depth, semi-structured interviews (recorded and later transcribed) as well as field notes from unstructured interviews (not recorded but documented in field notes, which were later digitalised and structured). The interviews were conducted in Uganda in 2022, with online follow-ups extending into 2023. The interviews took place in person in Kampala and in three of the country's official refugee settlements: Imvepi, Bidibidi, and Kyaka II. The participants included government officials, UNHCR representatives, NGO officials, and refugees, including those involved in refugee-led, community-based organisations.</p> <p>Due to the sensitive nature of the research, access to the files is restricted.</p>
Data set for the article 'Surfactant-Enhanced Formation of Ethylene from Carbon Monoxide Electroreduction on Copper Catalysts'
<p>This depository contains the data set for the article 'Surfactant-Enhanced Formation of Ethylene from Carbon Monoixde Electroreduction on Copper Catalysts', published in ACS Catalysis (<a title="DOI URL" href="https://doi.org/10.1021/acscatal.3c03576">https://doi.org/10.1021/acscatal.3c03576</a>).</p> <p> </p>
Suppelementary files for the article "A visualisation of flow dynamics in tide dominated unconfined coastal aquifers by using physical experiments"
Open the record for dataset details and reuse information.
Raw data for the figures in the preprint article arXiv:2402.09930
<p>Raw data for the figures in the preprint article arXiv:2402.09930.</p>
Raw data for the article: Living donor liver transplantation: an Italian single-center reappraisal
Open the record for dataset details and reuse information.
Dataset related to article: Psychosocial factors associated with workability after surgery in cancers survivors. an explorative study
<p><span>Dataset related to the statistical analysis performed to investigate the association between work ability and sociodemographic, clinical and psychological factors.</span></p>
Data set for the article 'Adsorbate Coverage Effects on the Electroreduction of CO to Acetate'
<p>This deposit contains the experimental data for the article 'Adsorbate Coverage Effects on the Electroreduction of CO to Acetate', published in Applied Catalysis B: Environment and Energy. Vol 352, p 124008, <strong>2024</strong>.</p>
Full-texts of articles in "GERONTOLOGIE CH. Praxis + Forschung" published by members of Swiss universities
<p>The swissuniversities-funded project GOAL (Unlocking the Green Open Access PotentiaL in scholarly and professional journals in Switzerland) aims to develop case scenarios for the semi-automatic inclusion of full-text articles from professional journals in Open Access repositories. These articles originate from journals with which the project has successfully negotiated self-archiving rights. To this end, the project is testing semi-automated workflows that process and enrich bibliographic metadata and full-texts provided by two professional journals. The dataset contains all full-texts of articles mentioned in the CSV/Excel for the journal “GERONTOLOGIE CH. Praxis + Forschung”. All issues provided on the publisher’s website “Gerontologie CH.” were split into single PDFs/A (one PDF per article).</p>
Dataset for the article 'Toward Efficient Tandem Electroreduction of CO2 to Methanol using Anodized Titanium'
<p>This depository contains the dataset for the experiments performed for the publication 'Toward Efficient Tandem Electroreduction of CO2 to Methanol using Anodized Titanium', published in ACS Catalysis, <span>2021</span><span>, 11</span><span>, 14</span><span>, 8467–8475 (<a title="DOI URL" href="https://doi.org/10.1021/acscatal.1c01725">https://doi.org/10.1021/acscatal.1c01725</a>).</span></p>
Dataset related to the article "Circulating mircoRNAs linked to inflammatory pathways are altered in subject with aortic valve sclerosis"
<p><span>Plasma miRNA profiling performed by HTG EdgeSeq miRNA whole transcriptome assay in subjects with and without aortic valve sclerosis (AVSc).</span></p>
Restricted Data Set for the article Analysing the impact of renewables on Iberian wholesale electricity market prices using machine learning techniques. Green Finance, 2024, 6 (2), 363-382
<p><span>Two of the series contained in the databases used in the article [</span><em><span>Analysing the impact of renewables on Iberian wholesale electricity market prices using machine learning techniques. Green Finance, 6 (2), 363-382</span></em><span>] are not authorized for public sharing. Specifically, these include the data corresponding to the Dutch TTF futures price and the API2 index. Consequently, they are deposited under restricted access.</span></p>
FIGURE. Illustration of Hedysarum sunhangii. a, plant; b, calyx; c, keel; d, standard; e, wings; f, mature article; g, seed; h, a single flower. Drawn from the holotype and isotype (a–h). in Hedysarum sunhangii (Fabaceae, Hedysareae), a new species from Pamir-Alay (Babatag Ridge - Uzbekistan)
FIGURE. Illustration of Hedysarum sunhangii. a, plant; b, calyx; c, keel; d, standard; e, wings; f, mature article; g, seed; h, a single flower. Drawn from the holotype and isotype (a–h).
Dataset related to article "Peripheral blood mononuclear cell activation sustains seizure activity"
<p>Emerging data propose innate and adaptive immune cells as possible triggers of ictogenesis. Activated immune cells induce blood-brain barrier (BBB) permeability changes responsible for the extravasation into the brain parenchyma of serum proteins and other inflammatory mediators that promote neuroinflammation and seizures.The identification of cellular and soluble biomarkers that describe these processes is mandatory to better understand dysimmune encephalopathies with seizures.</p>
Dataset related to article "Circulating and synovial Pentraxin-3 (PTX3) expression levels correlate with rheumatoid arthritis severity and tissue infiltration indepndently of comventional treatements response."
<p>This record contains raw data related to article “Circulating and synovial Pentraxin-3 (PTX3) expression levels correlate with rheumatoid arthritis severity and tissue infiltration indepndently of comventional treatements response."</p> <p><strong>Aims: </strong>To determine the relationship between PTX3 systemic and synovial levels and the clinical features of rheumatoid arthritis (RA) in a cohort of early, treatment naïve patients and to explore the relevance of PTX3 expression in predicting response to conventional-synthetic (cs) Disease-Modifying-Anti-Rheumatic-Drugs (DMARDs) treatment.</p> <p><strong>Methods: </strong>PTX3 expression was analyzed in 119 baseline serum samples from early naïve RA patients, 95 paired samples obtained 6-months following the initiation of cs-DMARDs treatment and 43 healthy donors. RNA-sequencing analysis and immunohistochemistry for PTX3 were performed on a subpopulation of 79 and 58 synovial samples, respectively, to assess PTX3 gene and protein expression. Immunofluorescence staining was performed to characterize PTX3 expressing cells within the synovium.</p> <p><strong>Results: </strong>Circulating levels of PTX3 were significantly higher in early RA compared to healthy donors and correlated with disease activity at baseline and with the degree of structural damages at 12-months. Six-months after commencing cs-DMARDs, a high level of PTX3, proportional to the baseline value, was still detectable in the serum of patients, regardless of their response status. RNA-seq analysis confirmed that synovial transcript levels of PTX3 correlated with disease activity and the presence of mediators of inflammation, tissue remodeling and bone destruction at baseline. PTX3 expression in the synovium was strongly linked to the degree of immune cell infiltration, the presence of ectopic lymphoid structures and seropositivity for autoantibodies. Accordingly, PTX3 was found to be expressed by numerous synovial cell types such as plasma cells, fibroblasts, vascular and lymphatic endothelial cells, macrophages, and neutrophils. The percentage of PTX3-positive synovial cells, although significantly reduced at 6-months post-treatment as a result of global decreased cellularity, was similar in cs-DMARDs responders and non-responders.</p> <p><strong>Conclusion: </strong>This study demonstrates that, early in the disease and prior to treatment modification, the level of circulating PTX3 is a reliable marker of RA activity and predicts a high degree of structural damages at 12-months. In the joint, PTX3 associates with immune cell infiltration and the presence of ectopic lymphoid structures. High synovial and peripheral blood levels of PTX3 are associated with chronic inflammation characteristic of RA. Additional studies to determine the mechanistic link are required.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.