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Dataset results
2,096 results for “Tracts”
microRNA expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_1]
GEO Series GSE112405. Homo sapiens. 3 samples. Type: Non-coding RNA profiling by array.
Transcriptional repression and apoptosis influence the effect of APOBEC3A/3B functional polymorphisms on biliary tract cancer risk
GEO Series GSE166372. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Tissue resident memory T cells populate the human uveal tract
GEO Series GSE308887. Homo sapiens. 22 samples. Type: Other; Expression profiling by high throughput sequencing.
microRNA expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_2]
GEO Series GSE112406. Homo sapiens. 19 samples. Type: Non-coding RNA profiling by array.
Human GI tract samples of Lactobacillus plantarum 299v
GEO Series GSE17634. Lactiplantibacillus plantarum; Lactiplantibacillus plantarum WCFS1. 4 samples. Type: Expression profiling by array.
Investigation into the Physiologies of Aeromonas veronii in vitro and Inside the Digestive-Tract of the Medicinal Leech using RNA-seq
GEO Series GSE38068. Aeromonas veronii. 3 samples. Type: Expression profiling by high throughput sequencing.
Effect of neuronal primary cilia on axonal tract development
GEO Series GSE120310. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Impact of oral compost-extract administration on gene expression in the rat gastrointestinal tract
GEO Series GSE37732. Rattus norvegicus. 4 samples. Type: Expression profiling by array.
A Conditional Mouse Expressing a Tumor-derived Mutation in the NRF2 Transcription Factor Displays Hyperplasia of the Upper Gastrointestinal Tract and Decreased White Adipose Fat
GEO Series GSE141311. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
microRNA and geneexpression profiles in organoids derived from biliary tract carcinomas
GEO Series GSE112408. Homo sapiens. 50 samples. Type: Non-coding RNA profiling by array; Expression profiling by array.
Single nucleus transcriptomes from post-synaptic targets of the corticospinal tract with respect to laterality.
GEO Series GSE277618. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Translocation driven high expression of NOTCH2 in glomus tumors of the upper digestive tract
GEO Series GSE118896. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Identification of Crohn’s disease subtypes in single cell RNA sequencing signatures of treatment naïve samples across the gastrointestinal tract
GEO Series GSE290695. Homo sapiens. 95 samples. Type: Expression profiling by high throughput sequencing.
Patient-Derived Xenografts of Upper Tract Urothelial Cell Carcinoma: a tool for precision medicine
GEO Series GSE134292. Homo sapiens. 80 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of Lactobacillus casei Zhang in fermented milk during transit in simulated gastrointestinal tract
GEO Series GSE23685. Lacticaseibacillus casei str. Zhang. 12 samples. Type: Expression profiling by array.
Envafolimab and Chidamide in combination with GEMOX as first-line treatment for advanced and metastatic biliary tract cancer (B-Enefits/SCOG-B001): A single-arm, exploratory, phase 2 trial
GEO Series GSE301188. Homo sapiens; Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity"
<p>This record contains raw data related to article “Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity"</p> <p><strong>Introduction: </strong>Biliary tract cancers (BTC) are rare malignancies arising from biliary system. Systemic therapy is the cornerstone for stage IV disease, with poor overall survival (OS). Evidence is lacking about safety and efficacy of local ablative treatments, such as surgery and stereotactic body radiotherapy (SBRT) in the context of metastatic BTC (mBTC).</p> <p><strong>Materials and methods: </strong>We retrospectively analyzed clinical outcomes for a cohort of mBTC patients treated with SBRT for oligometastatic disease. Inclusion criteria were 1-5 distant metastases; SBRT with a dose/fraction of a least 5 Gy to a biological effective dose (BED) of at least 40 Gy considering an α/β of 10 Gy. Analyzed outcomes included local control (LC), distant progression-free survival (DPFS), PFS, and OS.</p> <p><strong>Results: </strong>51 patients meeting the inclusion criteria. Primary tumor sites were intrahepatic cholangiocarcinoma (35%), extrahepatic cholangiocarcinoma (31%), ampullary adenocarcinoma (20%), gallbladder adenocarcinoma (14%). 21 patients were treated on liver lesions, 17 on nodal metastasis, 5 patients on lung lesions, 4 patients on recurrence along the extrahepatic bile duct. After a median follow-up of 14 months median OS was 13.7 months, 1- and 2-year OS were 58% and 41%, respectively. Node and lung as metastatic sites were associated with a longer OS (p < 0.001). Median LC was 26.8 months, and intrahepatic cholangiocarcinoma was associated with longer LC (p = 0.036). Median DPFS was 11 months, with 1- and 2-year DPFS of 48% and 27.8%, respectively. Ten patients reported grade 1-2 toxicity and 2 cases of acute G3 biliary obstruction.</p> <p><strong>Conclusions: </strong>Stereotactic body radiotherapy (SBRT) is feasible in the context of mBTC. OS and PFS results are promising, considering that our patients were heavily pre-treated with systemic therapy. Patients with nodal or lung relapse have better prognosis. Distant relapses remain the main pattern of failure, but treatment of all metastatic sites seems to improve DMFS.</p>
Clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large B cell lymphoma (DLBCL) reveals gain at 1q31 and RGS1 encoding protein; high RGS1 immunohistochemical expression associates with poor overall survival in DLBCL not otherwise specified (NOS)
<p>Raw annonymized data, OncoScan CEL files of the manuscript.</p> <p>PMID: 27775850</p> <p>DOI: 10.1111/his.13106</p> <p>ABSTRACT:</p> <p><strong>Aims: </strong> We aimed to define the clinicopathological characteristics of 29 primary sinonasal diffuse large B cell lymphoma (DLBCL<sup>sn</sup> ) in a series of 240 cases of DLBCL not otherwise specified [DLBCL<sup>all (</sup><sup>NOS</sup><sup>)</sup> ], including DLBCL<sup>sn</sup> training set (n = 11) and validation set (n = 18), and DLBCL<sup>non-sn</sup> (n = 211).</p> <p><strong>Methods and results: </strong> In the training set, 82% had a non-germinal center B-cell-like (Hans' Classifier) (non-GCB) phenotype and 18% were Epstein-Barr virus-encoded small RNAs (EBER)<sup>+</sup> . The genomic profile showed gains<sup>(+)</sup> of 1q21.3q31.2 (55%), 10q24.1 (46%), 11q14.1 (46%) and 18q12.1q23 (46%); losses<sup>(-)</sup> of 6q26q27 (55%) and 9p21.3 (64%); and copy number neutral loss of heterozygosity (LOH) (acquired uniparental disomy, UPD) at 6p25.3p21.31 (36%). This profile is comparable to DLBCL<sup>NOS</sup> (GSE11318, n = 203.) and closer to non-GCB/activated B-cell-like subtype (ABC). Nevertheless, +1q31, -9p21.3 and -10q11.1q26.2 were more characteristic of DLBCL<sup>sn</sup> (P < 0.001). Array results were verified successfully by fluorescence in situ hybridization (FISH) on +1q21.3 (CKS1B), -6q26 (PARK2), +8q24.21 (MYC), -9p21.3 (MTAP, CDKN2A/B), -17p13.1 (TP53) and +18q21.33 (BCL2) with 82-91% agreement. Minimal common regions included biologically relevant genes of MNDA (+1q23.1), RGS1 and RGS13 (+1q31.2), FOXP1 (+3p13), PRDM1 (BLIMP1) and PARK2 (-6q21q26), MYC (+8q24.21), CDKN2A (-9p21.3), PTEN (-10q23.31), MDM2 (+12q15), TP53 (-17p13.1) and BCL2 (+18q21.33). Correlation between DNA copy number and protein immunohistochemistry was confirmed for RGS1, RGS13, FOXP1, PARK2 and BCL2. The microenvironment had high infiltration of M2-like tumour associated macrophages (TAMs) and CD8<sup>+</sup> T lymphocytes that associated with higher genomic instability. The DLBCL<sup>sn</sup> validation set confirmed the clinicopathological characteristics, all FISH loci and immunohistochemistry (IHC) for RGS1. RGS1, one of the most frequently altered genes, was analysed by IHC in DLBCL<sup>all</sup> and high RGS1 expression associated with non-GCB, EBER<sup>+</sup> and unfavourable overall survival (hazard ratio = 1.794; P = 0.016).</p> <p><strong>Conclusions: </strong> DLBCL<sup>sn</sup> has a characteristic genomic profile. High RGS1 IHC expression associates with poor overall survival in DLBCL<sup>all (</sup><sup>NOS</sup><sup>)</sup> .</p>
Expanded Access Use of Sulopenem Etzadroxil/Probenecid for Complicated Urinary Tract Infection
ClinicalTrials.gov study NCT04682834. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Altered gene expression in the lower expiratory tract of Car6-/- mice
GEO Series GSE73755. Mus musculus. 32 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.