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ECG-based score estimates the probability to detect Fabry Disease cardiac involvement
<p>Figliozzi S, Camporeale A, Boveri S, Pieruzzi F, Pieroni M, Lusardi P, Spada M, Mignani R, Burlina A, Graziani F, Pica S, Tondi L, Bernardini A, Chow K, Namdar M, Lombardi M. ECG-based score estimates the probability to detect Fabry Disease cardiac involvement. Int J Cardiol. 2021 Sep 15;339:110-117. doi: 10.1016/j.ijcard.2021.07.022. Epub 2021 Jul 16. PMID: 34274410.</p> <p>Abstract</p> <p><strong>Objectives: </strong>To elaborate an ECG-based nomogram estimating the probability to detect cardiac involvement by cardiac magnetic resonance (CMR) in Fabry Disease (FD).</p> <p><strong>Methods: </strong>119 FD patients and 26 healthy controls underwent ECG and CMR. Test (n = 88, 60%) and validation cohorts (n = 57, 40%) were randomly derived. Cardiac involvement was defined as the presence of low myocardial T1 value, a CMR-surrogate of myocardial glycosphingolipid storage. ECG changes associated with low T1 value were identified in the test cohort, included in the nomogram and then tested in the validation cohort.</p> <p><strong>Results: </strong>Sokolow-Lyon index (AUC = 0.769), ratio between P-wave and PR-segment durations (Pwave/PRsegment) (AUC = 0.778), QRS duration (AUC = 0.703), QT (AUC = 0.769) duration were independently associated with the presence of low T1 on CMR at multivariate analysis. An ECG-based nomogram including these four parameters was accurate in identifying patients with CMR evidence of glycosphingolipid storage (c-index of the derived-nomogram = 0.90 in the test group; 0.81 in the validation group).</p> <p><strong>Conclusion: </strong>We propose a practical ECG-based nomogram accurately estimating the probability to detect low T1 values by CMR in FD patients. The application of this tool in clinical practice could improve early detection of FD cardiac involvement.</p>
Dataset related to article "Is the Instability Severity Index Score a Valid Tool for Predicting Failure After Primary Arthroscopic Stabilization for Anterior Glenohumeral Instability?"
<p>This record contains raw data related to article “Is the Instability Severity Index Score a Valid Tool for Predicting Failure After Primary Arthroscopic Stabilization for Anterior Glenohumeral Instability?”.</p> <p><strong>Abstract</strong></p> <p><strong>Purpose: </strong>To assess the validity of the Instability Severity Index Score in predicting the rate of recurrence of dislocation in patients undergoing arthroscopic Bankart repair.</p> <p><strong>Methods: </strong>The inclusion criteria were recurrent anterior traumatic glenohumeral instability and a minimum follow-up of 5 years. According to the preoperative Instability Severity Index Score, patients were divided into the following groups: ≤3 points (A), 4 to 6 points (B), and >6 points (C). The recurrence rate was determined by telephone interviews. The estimated overall rate of success at 5 years was defined as the estimated overall percentage of patients free of recurrence at 5 years.</p> <p><strong>Results: </strong>Six hundred seventy patients (572 men and 98 women) were included. The average age was 27 years (range, 18 to 39 years) at the time of surgery. One hundred fourteen of 670 patients had a recurrence of instability, with an overall recurrence rate of 17% (95% confidence interval [CI] 14.2%-19.9%). The Instability Severity Index Score had a significant association with recurrence. Compared with patients in group A, those in group B had double the risk of recurrence (hazard ratio [HR] = 2.43, 95% CI 1.38-4.28, P = .002), and patients in group C a 9 times greater risk of recurrence (HR = 9.42, 95% CI 5.20-17.7, P < .001). The estimated overall rate of success at 5 years was 84.8% (95% CI 81.8-87.3). The rate of success with an Instability Severity Index Score ≤3 points was 93.7% (95% CI 89.6-96.2), but it dropped to 85.7% (95% CI 81.7-88.9) in those with an Instability Severity Index Score of 4 to 6 points and became 54.6% (95% CI 42.8-64.9) in those with an Instability Severity Index Score >6 points. On multivariable analysis, the Instability Severity Index Score was found to significantly affect the risk of recurrence, corrected by type of sport and glenoid bone loss.</p> <p><strong>Conclusions: </strong>The Instability Severity Index Score is a validated tool with which to assess the recurrence rate of dislocation after arthroscopic surgery in patients with shoulder instability. Arthroscopic stabilization in patients with an Instability Severity Index Score ≤3 is associated with a significantly lower risk of recurrence of glenohumeral instability compared with that in patients with an Instability Severity Index Score >3 points.</p> <p><strong>Level of evidence: </strong>III, case-control study.</p>
Visual Function Score: A New Clinical Tool to Assess Visual Function and Detect Visual Disorders in Children
<p>The database contains in the first sheet the raw data derived from the administration of the Visual Function Score (VFS) to a sample of 100 visually impaired children. VFS is a quantitative tool conceived for the assessment of visual functions in children and is thoroughly described in the article.</p> <p>For each item of the VFS, the clinicians assigned a score according to the instructions provided with the template in the original article. The total score of a subject is defined as the weighted sum of the 51 items of the second section (columns L-BJ of the spreadsheet) which is normalized to obtain a score from 0 to 100. The scoring system is described in the second sheet (‘encoding’) together with the meaning of the items. </p>
Raw Data_Inflammation-based Glasgow Prognostic Score level and mortality in patients with cardiovascular disease: the National and Health Nutrition Examination Survey 1999-2010
<p>The raw data supporting the results of this study (Inflammation-based Glasgow Prognostic Score level and mortality in patients with cardiovascular disease: the National and Health Nutrition Examination Survey 1999-2010)</p>
Data set for "Hemoglobin, albumin, lymphocyte, and platelet score: A risk prediction tool for incidence and mortality in diabetic kidney disease patients with type 2 diabetes "
Open the record for dataset details and reuse information.
Dataset related to article "Are nephrometry scores accurate for the prediction of outcomes in patients with renal angiomyolipoma treated with robot-assisted partial nephrectomy? A multi-institutional analysis "
<p>This record contains raw data related to article “Are nephrometry scores accurate for the prediction of outcomes in patients with renal angiomyolipoma treated with robot-assisted partial nephrectomy? A multi-institutional analysis"</p> <p><strong>Purpose: </strong> Prediction of complications and surgical outcomes is of outmost importance even in patients with benign renal masses. The aim of our study is to test the PADUA, SPARE and R.E.N.A.L. scores to predict nephron sparing surgery (NSS) outcomes in patients presenting with renal angiomyolipoma (RAML).</p> <p><strong>Methods: </strong> We retrospectively analyzed the clinical and pathological data of 93 patients with AML treated with robot-assisted partial nephrectomy (RAPN) at three tertiary care referral centers. Renal masses were classified according to the PADUA, SPARE and R.E.N.A.L. nephrometry scores. Surgical success was defined according to the novel Trifecta score. Logistic regression models (LRM) were fitted to predict the achievement of novel Trifecta and the risk of high-grade Clavien-Dindo (CD) complication. The receiver operating characteristics (ROC) curve analysis was used to estimate the accuracy of LRMs.</p> <p><strong>Results: </strong> Of 93 patients, 66 (69.9%) were females; median tumor size was 42 (36-48) mm. Novel Trifecta was achieved in 79 patients (84.9%) and post-operative complications classified as CD>2 occurred in 7 (7.5%) patients. At univariate and multivariate LRMs all three nephrometry scores were significantly associated with novel Trifecta achievement. Similar findings were observed for the prediction of CD>2 complications. The AUCs to predict optimal surgical outcomes and CD>2 complications were 0.791 and 0.912 for PADUA, 0.767 and 0.836 for SPARE and 0.756 and 0.842 for RENAL score, respectively.</p> <p><strong>Conclusions: </strong> RAPN appears to be a feasible and safe surgical technique for the treatment of RAML. PADUA, SPARE and RENAL scores can be safely adopted to predict surgical outcomes, with the first one showing a higher accuracy.</p> <p> </p>
Dtaset related to the article The double anaerobic threshold in heart failure: MECKI score database overview. ESC Heart Fail. 2022;9:2119-2124.
<p> </p> <p><strong>Aims: </strong>In heart failure (HF), anaerobic threshold (AT) may be indeterminable but its value held a relevant prognostic role. AT is evaluated joining three methods: V-slope, ventilatory equivalent, and end-tidal methods. The possible non-concordance between the V-slope (met AT) and the other two methods (vent AT) has been highlighted in healthy individuals and named double threshold (DT).</p> <p><strong>Methods and results: </strong>We reanalysed 1075 cardiopulmonary exercise tests of HF patients recruited in the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score database. We identified DT in 43% of cases. Met AT precedes vent AT being met-ventΔVO<sub>2</sub> 221 (interquartile range: 129-319) mL/min. Peak VO<sub>2</sub> , 1307 ± 485 vs. 1343 ± 446 mL/min (63 ± 17 vs. 63 ± 17 percentage of predicted), was similar between DT+ and DT- patients. Differently, DT+ showed a lower ventilatory vs. carbon dioxide production (VE/VCO<sub>2</sub> ) slope (29.6 ± 6.1 vs. 31.0 ± 6.3), a lower peak exercise end-tidal oxygen tension (PetO<sub>2</sub> ) 115.3 (111.5-118.9) vs. 116.4 (112.4-120.2) mmHg, and a higher carbon dioxide tension (PetCO<sub>2</sub> ) 34.2 (30.9-37.1) vs. 32.4 (28.7-35.5) mmHg. Vent AT showed a significant higher VO<sub>2</sub> , 957 ± 318 vs. 719 ± 252 mL/min, VCO<sub>2</sub> , 939 ± 319 vs. 627 ± 226 mL/min, ventilation, 31.0 ± 8.3 vs. 22.5 ± 6.3 L/min, respiratory exchange ratio, 0.98 ± 0.08 vs. 0.87 ± 0.07, PetO<sub>2</sub> , 108 (104-112) vs. 105 (101-109) mmHg, PetCO<sub>2</sub> , 37 (34-40) vs. 36 (33-39) mmHg, and VE/VO<sub>2</sub> ratio, 33.5 ± 6.7 vs. 32.6 ± 6.9, but lower VE/VCO<sub>2</sub> ratio, 33 (30-37) vs. 36 (32-41), compared with met AT. At 2 year survival by Kaplan-Meier analysis, even adjusted for confounders, DT resulted not associated with survival.</p> <p><strong>Conclusions: </strong>Double threshold is frequently observed in HF patients. DT+ is associated to a decreased ventilatory response during exercise.</p> <p> </p>
Raw data of the publication: Does moderate hyperkalemia influence survival in HF? Insights from the MECKI score data (Int J Cardiol . 2023 Jan 15;371:273-277. doi: 10.1016/j.ijcard.2022.09.030. Epub 2022 Sep 15)
<p><strong>Background: </strong>The prognostic role of moderate hyperkalemia in reduced ejection fraction (HFrEF) patients is still controversial. Despite this, it affects the use of renin-angiotensin-aldosterone system inhibitors (RAASi) with therapy down-titration or discontinuation.</p> <p><strong>Objectives: </strong>Aim of the study was to assess the prognostic impact of moderate hyperkalemia in chronic HFrEF optimally treated patients.</p> <p><strong>Methods and results: </strong>We retrospectively analyzed MECKI (Metabolic Exercise test data combined with Cardiac and Kidney Indexes) database, with median follow-up of 4.2 [IQR 1.9-7.5] years. Data on K<sup>+</sup> levels were available in 7087 cases. Patients with K<sup>+</sup> plasma level ≥ 5.6 mEq/L and < 4 mEq/L were excluded. Remaining patients were categorized into normal >4 and < 5 mEq/L (n = 4826, 68%) and moderately high ≥5.0 and ≤ 5.5 mEq/L (n = 496, 7%) K<sup>+</sup>. Then patients were matched by propensity score in 484 couplets of patients. MECKI score value was 7% [IQR 3.1-14.1%] and 7.3% [IQR 3.4-15%] (p = 0.678) in patients with normal and moderately high K<sup>+</sup> values while cardiovascular mortality events at two years follow-up were 41 (4.2%) and 33 (3.4%) (p = 0.333) in each group respectively.</p> <p><strong>Conclusions: </strong>Moderate hyperkalemia does not influence patients' outcome in a large cohort of ambulatory HFrEF patients.</p>
Dataset related to the article "AI-SCoRE (artificial intelligence-SARS CoV2 risk evaluation): a fast, objective and fully automated platform to predict the outcome in COVID-19 patients"
<p>This record contains partial raw data related to the article “AI-SCoRE (artificial intelligence-SARS CoV2 risk evaluation): a fast, objective and fully automated platform to predict the outcome in COVID-19 patients”</p> <p><strong>Purpose: </strong>To develop and validate an effective and user-friendly AI platform based on a few unbiased clinical variables integrated with advanced CT automatic analysis for COVID-19 patients' risk stratification.</p> <p><strong>Material and methods: </strong>In total, 1575 consecutive COVID-19 adults admitted to 16 hospitals during wave 1 (February 16-April 29, 2020), submitted to chest CT within 72 h from admission, were retrospectively enrolled. In total, 107 variables were initially collected; 64 extracted from CT. The outcome was survival. A rigorous AI model selection framework was adopted for models selection and automatic CT data extraction. Model performances were compared in terms of AUC. A web-mobile interface was developed using Microsoft PowerApps environment. The platform was externally validated on 213 COVID-19 adults prospectively enrolled during wave 2 (October 14-December 31, 2020).</p> <p><strong>Results: </strong>The final cohort included 1125 patients (292 non-survivors, 26%) and 24 variables. Logistic showed the best performance on the complete set of variables (AUC = 0.839 ± 0.009) as in models including a limited set of 13 and 5 variables (AUC = 0.840 ± 0.0093 and AUC = 0.834 ± 0.007). For non-inferior performance, the 5 variables model (age, sex, saturation, well-aerated lung parenchyma and cardiothoracic vascular calcium) was selected as the final model and the extraction of CT-derived parameters was fully automatized. The fully automatic model showed AUC = 0.842 (95% CI: 0.816-0.867) on wave 1 and was used to build a 0-100 scale risk score (AI-SCoRE). The predictive performance was confirmed on wave 2 (AUC 0.808; 95% CI: 0.7402-0.8766).</p> <p><strong>Conclusions: </strong>AI-SCoRE is an effective and reliable platform for automatic risk stratification of COVID-19 patients based on a few unbiased clinical data and CT automatic analysis.</p>
Abdominal obesity phenotype is associated with COVID-19 chest X-ray severity score better than BMI-based obesity
<p>Malavazos AE, Secchi F, Basilico S, Capitanio G, Boveri S, Milani V, Dubini C, Schiaffino S, Morricone L, Foschini C, Gobbo G, Piccinni R, Saibene A, Sardanelli F, Menicanti L, Guazzi M, Dong C, Romanelli MMC, Carruba M, Iacobellis G. Abdominal obesity phenotype is associated with COVID-19 chest X-ray severity score better than BMI-based obesity. Eat Weight Disord. 2022 Feb;27(1):345-359. doi: 10.1007/s40519-021-01173-w. Epub 2021 Apr 5. PMID: 33821453; PMCID: PMC8020829.</p> <p>Abstract</p> <p><strong>Purpose: </strong>Chest X-ray (CXR) severity score and BMI-based obesity are predictive risk factors for COVID-19 hospital admission. However, the relationship between abdominal obesity and CXR severity score has not yet been fully explored.</p> <p><strong>Methods: </strong>This retrospective cohort study analyzed the association of different adiposity indexes, including waist circumference and body mass index (BMI), with CXR severity score in 215 hospitalized patients with COVID-19.</p> <p><strong>Results: </strong>Patients with abdominal obesity showed significantly higher CXR severity scores and had higher rates of CXR severity scores ≥ 8 compared to those without abdominal obesity (P < 0.001; P = 0.001, respectively). By contrast, patients with normal weight, with overweight and those with BMI-based obesity showed no significant differences in either CXR severity scores or in the rates of CXR severity scores ≥ 8 (P = 0.104; P = 0.271, respectively). Waist circumference and waist-to-height ratio (WHtR) correlated more closely with CXR severity scores than BMI (r = 0.43, P < 0.001; r = 0.41, P < 0.001; r = 0.17, P = 0.012, respectively). The area under the curves (AUCs) for waist circumference and WHtR were significantly higher than that for BMI in identifying a high CXR severity score (≥ 8) (0.68 [0.60-0.75] and 0.67 [0.60-0.74] vs 0.58 [0.51-0.66], P = 0.001). A multivariate analysis indicated abdominal obesity (risk ratio: 1.75, 95% CI: 1.25-2.45, P < 0.001), bronchial asthma (risk ratio: 1.73, 95% CI: 1.07-2.81, P = 0.026) and oxygen saturation at admission (risk ratio: 0.96, 95% CI: 0.94-0.97, P < 0.001) as the only independent factors associated with high CXR severity scores.</p> <p><strong>Conclusion: </strong>Abdominal obesity phenotype is associated with a high CXR severity score better than BMI-based obesity in hospitalized patients with COVID-19. Therefore, when visiting the patient in a hospital setting, waist circumference should be measured, and patients with abdominal obesity should be monitored closely. Level of evidence Cross-sectional descriptive study, Level V.</p> <p> </p>
Deidentified Data Set For The Impact of Interviewer Characteristics on Residency Candidate Scores
<p>Interviewers with lower academic rank had higher odds of changing their post-discussion scores of residency candidates compared to professors. Future work is needed to further characterize the influencing factors and could help create more equitable decision processes during the residency candidate ranking process.</p>
(Tiny) Music Score Generation Dataset
<p>This dataset is a much smaller version of the Music Score Generation Dataset from the thesis on automatic score-to-score music generation</p>
Raw data for "The importance of re-evaluating the risk score in heart failure patients: An analysis from the Metabolic Exercise Cardiac Kidney Indexes (MECKI) score database" 2023 Int J Cardiol
<p>Abstract</p> <p><strong>Background: </strong>The role of risk scores in heart failure (HF) management has been highlighted by international guidelines. In contrast with HF, which is intrinsically a dynamic and unstable syndrome, all its prognostic studies have been based on a single evaluation. We investigated whether time-related changes of a well-recognized risk score, the MECKI score, added prognostic value. MECKI score is based on peak VO<sub>2</sub>, VE/VCO<sub>2</sub> slope, Na<sup>+</sup>, LVEF, MDRD and Hb.</p> <p><strong>Methods: </strong>A multi-centre retrospective study was conducted involving 660 patients who performed MECKI re-evaluation at least 6 months apart. Based on the difference between II and I evaluation of MECKI values (MECKI II - MECKI I = ∆ MECKI) the study population was divided in 2 groups: those presenting a score reduction (∆ MECKI <0, i.e. clinical improvement), vs. patients presenting an increase (∆ MECKI >0, clinical deterioration).</p> <p><strong>Results: </strong>The prognostic value of MECKI score is confirmed also when re-assessed during follow-up. The group with improved MECKI (366 patients) showed a better prognosis compared to patients with worsened MECKI (294 patients) (p < 0.0001). At 1st evaluation, the two groups differentiated by LVEF, V<sub>E</sub>/VCO<sub>2</sub> slope and blood Na<sup>+</sup> concentration, while at 2nd evaluation they differentiated in all 6 parameters considered in the score. The patients who improved MECKI score, improved in all components of the score but hemoglobin, while patients who worsened the score, worsened all parameters.</p> <p><strong>Conclusions: </strong>This study shows that re-assessment of MECKI score identifies HF subjects at higher risk and that score improvement or deterioration regards several MECKI score generating parameters confirming the holistic background of HF.</p>
Exosomal Prognostic Score (EXPS)-based Prognostic Model in Pancreatic Tumours: Construction and Validation
GEO Series GSE283773. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome of globus pallidus from a mouse having a high score of cocaine-dependent conditioned place preference
GEO Series GSE28528. Mus musculus. 4 samples. Type: Expression profiling by array.
Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.
<p>Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.</p> <p>This is the article:</p> <p><strong>Background: </strong> Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care platelet function tests (PFT).</p> <p><strong>Methods: </strong> The patient population consisted of 760 cardiac surgery patients where preoperative PFT (multiple-electrode aggregometry [MEA]) were available. Platelet count and function at the ADPtest and TRAPtest were compared in the overall population and separately in patients with or without residual effects of P2Y12 inhibitors.</p> <p><strong>Results: </strong> Women had a significantly (P = 0.001) higher platelet count but a non-significantly higher platelet reactivity to ADP. In clopidogrel-treated patients, the platelets ADP reactivity was significantly (P = 0.031) higher in women, and platelet count was the main determinant of platelet hyper-reactivity. Within patients under full clopidogrel effects, women with a platelet count ≥ 200,000 cells/μL had a significantly (P = 0.023) higher rate of high-on-treatment platelet reactivity (HTPR, 45.5%) with respect to males with a platelet count < 200,000 cells/μL (11.9%), with a relative risk of 6.2 (95% confidence interval 1.4-29).</p> <p><strong>Conclusions: </strong> Our findings confirm that women have a larger platelet count than men, and that this is associated to a trend towards a higher platelet reactivity. HTPR is largely represented in women with a high platelet count. This generates the hypothesis that women requiring P2Y12 inhibitors could potentially benefit from larger doses of drug or should be treated with anti-platelet agents with a low rate of HTPR.</p>
Data set from Ranucci M, Barile L, Ambrogi F, Pistuddi V; Surgical and Clinical Outcome Research (SCORE) Group. Discrimination and calibration properties of the hypotension probability indicator during cardiac and vascular surgery. Minerva Anestesiol. 2019 Jul;85(7):724-730. doi: 10.23736/S0375-9393.18.12620-4. Epub 2018 Nov 22. PMID: 30481996.
<p>Data set from Ranucci M, Barile L, Ambrogi F, Pistuddi V; Surgical and Clinical Outcome Research (SCORE) Group. Discrimination and calibration properties of the hypotension probability indicator during cardiac and vascular surgery. Minerva Anestesiol. 2019 Jul;85(7):724-730. doi: 10.23736/S0375-9393.18.12620-4. Epub 2018 Nov 22. PMID: 30481996.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Background: </strong> Hypotension during surgery is linked to postoperative complications. Recently, a new hemodynamic algorithm intended to predict hypotensive events (hypotension probability indicator [HPI]) has been developed. The aim of the present study is to test the discrimination and calibration properties of the HPI.</p> <p><strong>Methods: </strong> The intraoperative files of 23 patients undergoing cardiac and major vascular surgery receiving the HPI-based hemodynamic monitoring were retrospectively investigated for prediction of hypotensive events (mean arterial pressure <65 mmHg). The HPI was available at 20 seconds intervals; the values of HPI five to seven minutes before a hypotensive event (HPI5-7) were tested for discrimination and calibration.</p> <p><strong>Results: </strong> The HPI5-7 has a fair level of discrimination (area under the curve 0.768) and a poor calibration, due to overestimation of the hypotensive risk. At the observed prevalence, a cut-off value of 85% carries a sensitivity of 62.4% and a specificity of 77.7%, a negative predictive value (NPV) of 97.8% and a positive predictive value (PPV) of 12.6%; a value of 98% has a PPV of 64% and an NPV of 95.3%.</p> <p><strong>Conclusions: </strong> The HPI5-7 may offer some useful insights. Values ≤85% carry a clinically acceptable NPV for hypotensive events at the observed prevalence and may represent a "safe zone" during surgery. Values >85% do not carry enough PPV to trigger hemodynamic interventions, but represent a warning signal. Values >98% are highly suggesting a hypotensive event after 5-7 minutes. Further studies exploring the predictive ability of the HPI at different times are needed.</p>
Data set from Ranucci M, Barile L, Ambrogi F, Pistuddi V; Surgical and Clinical Outcome Research (SCORE) Group. Discrimination and calibration properties of the hypotension probability indicator during cardiac and vascular surgery. Minerva Anestesiol. 2019 Jul;85(7):724-730. doi: 10.23736/S0375-9393.18.12620-4. Epub 2018 Nov 22. PMID: 30481996.
<p>Data set from Ranucci M, Barile L, Ambrogi F, Pistuddi V; Surgical and Clinical Outcome Research (SCORE) Group. Discrimination and calibration properties of the hypotension probability indicator during cardiac and vascular surgery. Minerva Anestesiol. 2019 Jul;85(7):724-730. doi: 10.23736/S0375-9393.18.12620-4. Epub 2018 Nov 22. PMID: 30481996.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Background: </strong> Hypotension during surgery is linked to postoperative complications. Recently, a new hemodynamic algorithm intended to predict hypotensive events (hypotension probability indicator [HPI]) has been developed. The aim of the present study is to test the discrimination and calibration properties of the HPI.</p> <p><strong>Methods: </strong> The intraoperative files of 23 patients undergoing cardiac and major vascular surgery receiving the HPI-based hemodynamic monitoring were retrospectively investigated for prediction of hypotensive events (mean arterial pressure <65 mmHg). The HPI was available at 20 seconds intervals; the values of HPI five to seven minutes before a hypotensive event (HPI5-7) were tested for discrimination and calibration.</p> <p><strong>Results: </strong> The HPI5-7 has a fair level of discrimination (area under the curve 0.768) and a poor calibration, due to overestimation of the hypotensive risk. At the observed prevalence, a cut-off value of 85% carries a sensitivity of 62.4% and a specificity of 77.7%, a negative predictive value (NPV) of 97.8% and a positive predictive value (PPV) of 12.6%; a value of 98% has a PPV of 64% and an NPV of 95.3%.</p> <p><strong>Conclusions: </strong> The HPI5-7 may offer some useful insights. Values ≤85% carry a clinically acceptable NPV for hypotensive events at the observed prevalence and may represent a "safe zone" during surgery. Values >85% do not carry enough PPV to trigger hemodynamic interventions, but represent a warning signal. Values >98% are highly suggesting a hypotensive event after 5-7 minutes. Further studies exploring the predictive ability of the HPI at different times are needed.</p>
Long-term prognostic role of diabetes mellitus and glycemic control in heart failure patients with reduced ejection fraction: Insights from the MECKI Score database.
<p>Raw data of the paper: </p> <p>Long-term prognostic role of diabetes mellitus and glycemic control in heart failure patients with reduced ejection fraction: Insights from the MECKI Score database.</p> <p><strong>Background. </strong>The prognostic role of diabetes mellitus (DM) in heart failure (HF) patients is undefined, since DM is outweighed by several DM-related variables when confounders are considered. We determined the prognostic role of DM, treatment and glycemic control, in a real-life HF population.</p> <p><strong>Methods. </strong>3927 HF patients included in the Metabolic Exercise Cardiac Kidney Index (MECKI) score database were evaluated with median follow-up of 3.66 years (IQR 1.70-6.67). Data analysis considered survival between DM (n=897) vs. non-DM (n=3030) patients, and, in diabetics, between insulin (n=304), oral antidiabetics (n=479), and dietary only (n=88) treatments. The role of glycemic control was evaluated grouping DM patients according to glycated hemoglobin (HbA1c): <7% (n=266), 7.1-8% (n=133), >8% (n=149). All analyses were performed also adjusting for ejection fraction, renal function, hemoglobin, sodium, exercise peak oxygen uptake, and ventilation/carbon dioxide relationship slope. Study primary endpoint was the composite of cardiovascular death, urgent heart transplantation, or left ventricular assist device implantation. Secondary endpoints were cardiovascular and all causes death.</p> <p><strong>Results. </strong>For all endpoints, upon adjustment for confounders, DM status and insulin treatment or dietary regimen were not significantly associated with adverse long-term prognosis compared to non-DM and oral antidiabetic treated patients, respectively. A worse prognosis was observed in HbA1c >8% patients (Log-Rank p<0.001), even after correction for confounding factors. All results were replicated by hazard ratio analysis.</p> <p><strong>Conclusion. </strong>In HF patients, DM, insulin treatment and dietary regimen are not adverse outcome predictors. The only condition related to long-term prognosis considering potential confounders is poor glycemic control.</p>
Italian Normative Data for the Original Version of the Tower of London Test: A Bivariate Analysis on Speed and Accuracy Scores
<p>Dataset associated with the following article:</p> <p>Bruni F, Toraldo A, Scarpina F. Italian Normative Data for the Original Version of the Tower of London Test: A Bivariate Analysis on Speed and Accuracy Scores. <em>Assessment.</em> 2020 Sep 29:1073191120961834. doi: 10.1177/1073191120961834</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.